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L-天门冬氨酸钠

L-天门冬氨酸钠用途

L-天冬氨酸二钠是一种氨基酸,可作为结肠靶向药物释放的合适前药[1][2]。

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L-天门冬氨酸钠名称

[ CAS 号 ]:
5598-53-8

[ 中文名 ]:
L-天冬氨酸钠

[ 英文名 ]:
MAGNESIUM L-ASPARTATE

[中文别名 ]:

L-天门冬氨酸钠

[英文别名 ]:

ASPARTIC ACID MAGNESIUM SALT
Magnesium (2S)-2-aminosuccinate
L-ASPARTATE SODIUM
H-ASP-ONA
L-ASPARTIC ACID MAGNESIUM SALT
asparginic acid disodium salt
Natriumasparaginat
L-Aspartic acid, magnesium salt (1:1)
sodium polyaspartate
H-ASP-OH NA

L-天门冬氨酸钠生物活性

[ 描述 ]:

L-天冬氨酸二钠是一种氨基酸,可作为结肠靶向药物释放的合适前药[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

[ 靶点 ]

Microbial Metabolite

Human Endogenous Metabolite

[参考文献]

[1]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.

[2]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.

L-天门冬氨酸钠物理化学性质

[ 密度 ]:
1.514g/cm3

[ 沸点 ]:
264.1ºC at 760mmHg

[ 熔点 ]:
270-271ºC

[ 分子式 ]:
C₄H₅MgNO₄

[ 分子量 ]:
155.392

[ 闪点 ]:
113.5ºC

[ 精确质量 ]:
155.006897

[ PSA ]:
78.62000

[ 外观性状 ]:
白色到灰白色粉末

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

L-天门冬氨酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9450400

CHEMICAL NAME :: Aspartic acid, disodium salt, L-

CAS REGISTRY NUMBER :: 5598-53-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H5-N-O4.2Na

MOLECULAR WEIGHT :: 177.08

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 62,203,1990 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 500 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2 gm/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 500 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2 gm/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984

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L-天门冬氨酸钠安全信息

[ 危害码 (欧洲) ]:
Xi