1-Nitrosopiperazine
1-Nitrosopiperazine名称
[ CAS 号 ]:
5632-47-3
[ 英文名 ]:
1-Nitrosopiperazine
[英文别名 ]:
- 1-Nitrosopiperazine
- Piperazine, 1-nitroso-
1-Nitrosopiperazine物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
264.5±33.0 °C at 760 mmHg
[ 分子式 ]:
C4H9N3O
[ 分子量 ]:
115.134
[ 闪点 ]:
113.8±25.4 °C
[ 精确质量 ]:
115.074562
[ PSA ]:
44.70000
[ LogP ]:
0.18
[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C
[ 折射率 ]:
1.602
1-Nitrosopiperazine毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM2450000
- CHEMICAL NAME :
- Piperazine, 1-nitroso-
- CAS REGISTRY NUMBER :
- 5632-47-3
- BEILSTEIN REFERENCE NO. :
- 0112147
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C4-H9-N3-O
- MOLECULAR WEIGHT :
- 115.16
- WISWESSER LINE NOTATION :
- T6M DNTJ DNO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2260 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Lungs, Thorax, or Respiration - acute pulmonary edema Liver - fatty liver degeneration
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5400 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Reproductive - Tumorigenic effects - uterine tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 720 mg/kg/20W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Liver - tumors Blood - tumors
MUTATION DATA
- TYPE OF TEST :
- Host-mediated assay
- TEST SYSTEM :
- Rodent - mouse Bacteria - Escherichia coli
- DOSE/DURATION :
- 150 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 272,161,1992
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