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9,11-双脱氧-9Alpha,11Alpha-环氧基甲烷前列腺素F

用途

U-44069 是一种稳定的前列腺素 (PG) H2 类似物和有效的血管收缩剂。U-44069 诱导肾小球前血管 Ca2+ 流入。

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名称

[ CAS 号 ]:
56985-32-1

[ 中文名 ]:
9,11-双脱氧-9Alpha,11Alpha-环氧基甲烷前列腺素F

[ 英文名 ]:
U 44069

[中文别名 ]:

[英文别名 ]:

MFCD00135237

生物活性

[ 描述 ]:

U-44069 是一种稳定的前列腺素 (PG) H2 类似物和有效的血管收缩剂。U-44069 诱导肾小球前血管 Ca2+ 流入。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Simpson AW, et, al. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. FEBS Lett. 1986 Jun 9;201(2):301-5.

[2]. Loutzenhiser R, et, al. Reversal of renal and smooth muscle actions of the thromboxane mimetic U-44069 by diltiazem. Am J Physiol. 1986 Apr;250(4 Pt 2):F619-26.

物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
519.7±35.0 °C at 760 mmHg

[ 分子式 ]:
C₂₁H₃₄O₄

[ 分子量 ]:
350.49

[ 闪点 ]:
176.1±19.4 °C

[ 精确质量 ]:
350.245697

[ PSA ]:
66.76000

[ LogP ]:
3.88

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.548

[ 储存条件 ]:
-20°C，密闭，干燥

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H336

[ 补充危害声明 ]:
Repeated exposure may cause skin dryness or cracking.

[ 警示性声明 ]:
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
22-36

[ 危险品运输编码 ]:
UN1231 - class 3 - PG 2 - Methyl acetate, solution

文献

Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice.

Prostaglandins Leukot. Essent. Fatty Acids 76(5) , 299-308, (2007)

The role of endothelin, PAF and thromboxane A2 in airway hyperreactivity (AHR) to carbachol induced by ovalbumin sensitization and challenge in Balb/c mice was investigated. Ovalbumin sensitization an...

Glibenclamide inhibits agonist-induced vasoconstriction of placental chorionic plate arteries.

Placenta 27(6-7) , 660-8, (2006)

Preliminary data suggest that K(ATP) channels may be expressed in placental arteries and veins [Wareing M, Turner C, Greenwood SL, Baker PN, Fyfe GK. Expression of mRNA encoding K+ channels in chorion...

Substrate binding is the rate-limiting step in thromboxane synthase catalysis.

J. Biol. Chem. 276(18) , 14737-43, (2001)

Thromboxane synthase (TXAS) is a "non-classical" cytochrome P450. Without any need for an external electron donor, or for a reductase or molecular oxygen, it uses prostaglandin H2 (PGH2) to catalyze e...

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