9,11-双脱氧-9Alpha,11Alpha-环氧基甲烷前列腺素F
9,11-双脱氧-9Alpha,11Alpha-环氧基甲烷前列腺素F结构式
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常用名 | 9,11-双脱氧-9Alpha,11Alpha-环氧基甲烷前列腺素F | 英文名 | U 44069 |
|---|---|---|---|---|
| CAS号 | 56985-32-1 | 分子量 | 350.49 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 519.7±35.0 °C at 760 mmHg | |
| 分子式 | C21H34O4 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 176.1±19.4 °C | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice.
Prostaglandins Leukot. Essent. Fatty Acids 76(5) , 299-308, (2007) The role of endothelin, PAF and thromboxane A2 in airway hyperreactivity (AHR) to carbachol induced by ovalbumin sensitization and challenge in Balb/c mice was investigated. Ovalbumin sensitization and challenge induced significant AHR to carbachol in activel... |
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Glibenclamide inhibits agonist-induced vasoconstriction of placental chorionic plate arteries.
Placenta 27(6-7) , 660-8, (2006) Preliminary data suggest that K(ATP) channels may be expressed in placental arteries and veins [Wareing M, Turner C, Greenwood SL, Baker PN, Fyfe GK. Expression of mRNA encoding K+ channels in chorionic plate arteries and veins. J Soc Gynecol Investig 2004;11... |
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Substrate binding is the rate-limiting step in thromboxane synthase catalysis.
J. Biol. Chem. 276(18) , 14737-43, (2001) Thromboxane synthase (TXAS) is a "non-classical" cytochrome P450. Without any need for an external electron donor, or for a reductase or molecular oxygen, it uses prostaglandin H2 (PGH2) to catalyze either an isomerization reaction to form thromboxane A2 (TXA... |
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On the regulation of tone in vasa vasorum.
Cardiovasc. Res. 41(1) , 237-45, (1999) The vasa vasorum form a network of microvessels in and around the walls of large blood vessels and are thought to be necessary to delivery oxygenated blood to the outer parts of the vessel wall that are inadequately nourished by diffusion from luminal blood. ... |
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In vivo effects of a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) partial agonist, (+)5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]- bicyclohept-2-exo-yl]-heptenoic acid [(+)-S-145], on vascular, platelet and cardiac function.
J. Pharmacol. Exp. Ther. 272(2) , 799-807, (1995) A novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor ligand, (+)5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]-bicyclohept-2-e xo- yl]-heptenoic acid [(+)-S-145], was evaluated in guinea pigs to assess the in vivo pharmacodynamic profile of this compound a... |
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Identification of the substrate interaction site in the N-terminal membrane anchor segment of thromboxane A2 synthase by determination of its substrate analog conformational changes using high resolution NMR technique.
J. Biol. Chem. 275(52) , 40679-85, (2000) The present studies describe an investigation for the interaction of N-terminal membrane anchor domain of thromboxane A(2) synthase (TXAS) with its substrate analog in a membrane-bound environment using the two-dimensional NMR technique. TXAS and prostaglandi... |
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Resonance Raman investigation of the interaction of thromboxane synthase with substrate analogues.
Biochemistry 42(9) , 2542-51, (2003) Thromboxane synthase is a hemethiolate enzyme that catalyzes the isomerization of prostaglandin H2 to thromboxane A2. We report the first resonance Raman (RR) spectra of recombinant human thromboxane synthase (TXAS) in both the presence and the absence of sub... |
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Protein engineering of thromboxane synthase: conversion of membrane-bound to soluble form.
Arch. Biochem. Biophys. 416(1) , 38-46, (2003) Thromboxane A2 synthase (TXAS) binds to the endoplasmic reticulum membrane and catalyzes both an isomerization of prostaglandin H2 (PGH2) to form thromboxane A2 (TXA2) and a fragmentation of PGH2 to form 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and malo... |
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Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen.
Can. J. Physiol. Pharmacol. 89(5) , 329-34, (2011) Oxygen promotes closure of the ductus arteriosus at birth. We have previously presented a scheme for oxygen action with a cytochrome P450 (CYP450) hemoprotein and endothelin-1 (ET-1) being, respectively, sensor and effector, and a hypothetical monooxygenase p... |
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Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique.
Arch. Biochem. Biophys. 444(2) , 165-73, (2005) Understanding the docking mechanism of the common substrate, prostaglandin H(2) (PGH(2)), into the active sites of different cyclooxygenase(COX)-downstream synthases is a key step toward uncovering the molecular basis of the isomerization of PGH(2) to differe... |