异硫氰酸烯丙酯
异硫氰酸烯丙酯用途
用作油膏和芥子硬膏的抗刺激剂，也用于有机合成
【用途二】
用于制备食品添加剂、医药、杀虫剂、杀菌剂等
【用途三】
GB 2760--1996规定为暂时允许使用的食品用香料。主要用于配制香辛料和芥子型香精，供泡菜、罐头、沙司、调味料等用。
【用途四】
主要用于食品方面，除用于合成芥末外，还可用于辣酱油类、肉类（肉食加工品）、醋腌食品以及其他调味品。一般不用其原品而稀释使用。如醋腌食品，其用量为腌汁的10万-40万分之一左右。在医药方面，如少量内服，由于刺激中枢神经而有兴奋作用，所以可用作晕厥、假死期的药物。另外还可用作助消化药、牙痛药、头痛药、催吐药。作为杀菌剂，对于淋球菌浓度为4000-32000分之一，对于链球菌为1/40000。另外还具有防霉或防腐蚀的作用。其效力与安息香酸、二氧化硫相同。此外，该品用于有机合成中间体、重氮感光纸助剂、杀虫剂及杀菌剂等方面。
异硫氰酸烯丙酯名称
[ CAS 号 ]:
57-06-7
[ 中文名 ]:
异硫氰酸烯丙酯
[ 英文名 ]:
Allyl isothiocyanate
[中文别名 ]:
[英文别名 ]:
- FEMA 2034
- Redskin
- AITK
- 3-isothiocyanatoprop-1-ene
- carbospol
- senfoel
- Allyl isothiocyanate
- Allylsenfoel
- 1-Propene, 3-isothiocyanato-
- EINECS 200-309-2
异硫氰酸烯丙酯物理化学性质
[ 密度 ]:
0.9±0.1 g/cm3
[ 沸点 ]:
151.9±9.0 °C at 760 mmHg
[ 熔点 ]:
-80 °C
[ 分子式 ]:
C4H5NS
[ 分子量 ]:
99.154
[ 闪点 ]:
36.3±26.5 °C
[ 精确质量 ]:
99.014267
[ PSA ]:
44.45000
[ LogP ]:
1.77
[ 外观性状 ]:
无色或淡琥珀色油性液体
[ 蒸汽压 ]:
4.6±0.3 mmHg at 25°C
[ 折射率 ]:
1.485
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放
[ 稳定性 ]:
Stable. Combustible. Incompatible with oxidizing agents, acids, water, alcohols, strong bases, amines. Darkens on aging.
[ 水溶解性 ]:
2 g/L (20 ºC)
异硫氰酸烯丙酯MSDS
异硫氰酸烯丙酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NX8225000
- CHEMICAL NAME :
- Isothiocyanic acid, allyl ester
- CAS REGISTRY NUMBER :
- 57-06-7
- BEILSTEIN REFERENCE NO. :
- 0773748
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 36
- MOLECULAR FORMULA :
- C4-H5-N-S
- MOLECULAR WEIGHT :
- 99.16
- WISWESSER LINE NOTATION :
- SCN2U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 92 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Skin and Appendages - dermatitis, other (after systemic exposure)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 308 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 88 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5600 mg/kg/14D-C
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg/3D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 700 mg/kg/14D-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12875 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 gm/kg/12W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - increased incidence of tumors in susceptible strains Tumorigenic - facilitates action of known carcinogen
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 8-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 8-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TEST SYSTEM :
- Mammal - species unspecified
- DOSE/DURATION :
- 800 ug/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,111,1993 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,55,1985 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,55,1985 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,225,1974 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:TWA 0.3 mg/m3;STEL 0.6 mg/m3 JAN 1993
异硫氰酸烯丙酯安全信息
[ 符号 ]:
GHS02, GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H226-H301 + H331-H310-H315-H317-H319-H334-H410
[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P302 + P350-P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic
[ 风险声明 (欧洲) ]:
R10;R23/24/25;R36/37/38;R43;R50/53
[ 安全声明 (欧洲) ]:
S26-S36/37-S45-S60-S61-S36/37/39-S28B-S24-S16-S23
[ 危险品运输编码 ]:
UN 1545 6.1/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
NX8225000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1
[ 海关编码 ]:
29309070
异硫氰酸烯丙酯上下游产品
异硫氰酸烯丙酯上游产品
异硫氰酸烯丙酯下游产品
异硫氰酸烯丙酯制备
1.将烯丙基碘或烯丙基溴与硫氰酸钾溶于乙醇加热，待卤化钾完全析出后，加水，将异硫氰酸烯丙酯析出，蒸馏精制。实际收率为理论值的65%-70%。
异硫氰酸烯丙酯海关
[ 海关编码 ]: 2930909090
[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
异硫氰酸烯丙酯文献
J. Pharmacol. Sci. 125(1) , 91-8, (2014)
The acute peripheral neuropathy induced by oxaliplatin treatment occurs very frequently and is aggravated by exposure to cold. Goshajinkigan (GJG), a traditional Japanese (kampo) medicine, was recentl...
TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis.Am. J. Physiol. Gastrointest. Liver Physiol. 309 , G87-99, (2015)
Quiescent phases of inflammatory bowel disease (IBD) are often accompanied by chronic abdominal pain. Although the transient receptor potential vanilloid 1 (TRPV1) ion channel has been postulated as a...
Only a minority of broad-range detoxification genes respond to a variety of phytotoxins in generalist Bemisia tabaci species.Sci. Rep. 5 , 17975, (2015)
Generalist insect can utilize two different modes for regulating their detoxification genes, the constitutive mode and the induced mode. Here, we used the Bemisia tabaci sibling species MEAM1 and MED,...
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