氨基脲
氨基脲用途
有机合成原料，也是医药、农药的中间体和测定醛、酮的试剂。用于生产呋喃西啉、硝基呋喃妥因等药物。
氨基脲名称
[ CAS 号 ]:
57-56-7
[ 中文名 ]:
氨基甲酰肼
[ 英文名 ]:
Semicarbazide
[中文别名 ]:
[英文别名 ]:
- aminourea
- Urea,amino
- Aminomocovina
- Carbazamide
- Semikarbazid
- MFCD00042824
- Carbazinamide
- EINECS 200-339-6
- amino-ure
- Hydrazinecarboxamide
氨基脲物理化学性质
[ 密度 ]:
1.7±0.1 g/cm3
[ 沸点 ]:
186.3±23.0 °C at 760 mmHg
[ 熔点 ]:
175-185ºC /decomposes/
[ 分子式 ]:
CH5N3O
[ 分子量 ]:
75.070
[ 闪点 ]:
66.5±22.6 °C
[ 精确质量 ]:
75.043259
[ PSA ]:
81.14000
[ LogP ]:
-1.61
[ 蒸汽压 ]:
0.2±0.8 mmHg at 25°C
[ 折射率 ]:
1.602
[ 储存条件 ]:
室温
氨基脲MSDS
氨基脲毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VT2975000
- CHEMICAL NAME :
- Semicarbazide
- CAS REGISTRY NUMBER :
- 57-56-7
- BEILSTEIN REFERENCE NO. :
- 0506319
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C-H5-N3-O
- MOLECULAR WEIGHT :
- 75.09
- WISWESSER LINE NOTATION :
- ZVMZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 176 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 123 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 126 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 gm/kg/30W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
MUTATION DATA
- TYPE OF TEST :
- DNA repair
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 125 ug/well
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984
氨基脲安全信息
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
22
[ 安全声明 (欧洲) ]:
S22
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
氨基脲制备
1.尿素-水合肼合成法由尿素与水合肼缩合而得。将40%的水合肼和尿素按摩尔比1.515：1投入反应锅中混合，搅拌加热，于95-103℃回流8h。降温过滤，得氨基脲水溶液，可直接用于有机合成。有时候也将氨基脲水溶液加盐酸，放置后过滤，得到盐酸氨基脲[CAS：563-41-7]。盐酸氨基脲的熔点为175℃。
2.硫酸肼-氰酸钠法硫酸肼与氰酸钠反应制得。
氨基脲文献
J. Chromatogr. A. 1288 , 10-20, (2013)
A method to aid in the detection of the economically driven adulteration of fresh milk with a range of small, nitrogen containing compounds, including melamine, ammeline, ammelide, cyanuric acid, alla...
Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism.PLoS ONE 8(1) , e55255, (2013)
Novel classes of pain-relieving molecules are needed to fill the void between non-steroidal anti-inflammatory agents and narcotics. We have recently shown that intraplantar administration of sphingosi...
Functional modulation of vascular adhesion protein-1 by a novel splice variant.PLoS ONE 8(1) , e54151, (2013)
Vascular Adhesion Protein-1 (VAP-1) is an endothelial adhesion molecule belonging to the primary amine oxidases. Upon inflammation it takes part in the leukocyte extravasation cascade facilitating tra...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：氨基脲
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥199.9/1g
￥599.9/5g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁
产品详情：氨基脲
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥1663.0/25g
￥112.0/1g
￥397.0/5g
联系人：夏言
产品详情：[Perfemiker]氨基脲,6 wt. % (on silica gel)
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相关化合物
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