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硫代氨基脲

硫代氨基脲用途

氨基硫脲是杂环合成中众所周知的来源。氨基硫脲还被用于金属的分光光度检测、媒体通信和光存储方面的小工具应用【1】。

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硫代氨基脲名称

[ CAS 号 ]:
79-19-6

[ 中文名 ]:
灭鼠特

[ 英文名 ]:
Thiosemicarbazide

[中文别名 ]:

[英文别名 ]:

Thiosemicarbazide
N-aminothiourea
hydrazinecarbothioamide
EINECS 201-184-7
MFCD00007620

硫代氨基脲生物活性

[ 描述 ]:

氨基硫脲是杂环合成中众所周知的来源。氨基硫脲还被用于金属的分光光度检测、媒体通信和光存储方面的小工具应用【1】。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Sraa Abu-Melha. Pyridyl thiosemicarbazide: synthesis, crystal structure, DFT/B3LYP, molecular docking studies and its biological investigations.

硫代氨基脲物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
208.6±23.0 °C at 760 mmHg

[ 熔点 ]:
180-183 °C (dec.)(lit.)

[ 分子式 ]:
CH₅N₃S

[ 分子量 ]:
91.14

[ 闪点 ]:
80.0±22.6 °C

[ 精确质量 ]:
91.020416

[ PSA ]:
96.16000

[ LogP ]:
-1.15

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.667

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
soluble

硫代氨基脲MSDS

硫代氨基脲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT4200000

CHEMICAL NAME :: Semicarbazide, thio-

CAS REGISTRY NUMBER :: 79-19-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 22

MOLECULAR FORMULA :: C-H5-N3-S

MOLECULAR WEIGHT :: 91.15

WISWESSER LINE NOTATION :: ZMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9160 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16407 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Endocrine - hyperglycemia

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Ocular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 9100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1024 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2048 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 20 umol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,821,1976 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,111,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 72890 No. of Facilities: 435 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 4353 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 72890 No. of Facilities: 347 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1341 (estimated) No. of Female Employees: 1152 (estimated)

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硫代氨基脲安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R28;R52/53

[ 安全声明 (欧洲) ]:
S22-S26-S36/37-S45-S61-S28A

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
VT4200000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2942000000

硫代氨基脲合成路线

硫代氨基脲上下游产品

硫代氨基脲上游产品

硫代氨基脲下游产品

硫代氨基脲制备

以硫脲与水合肼为原料进行加热反应制得。

2.冷却条件下将31%～36%的盐酸加到30%的水合肼溶液中，使溶液ph值为3左右，在搅拌下加入过量的98%的硫氰化铵溶液，控制温度在30℃以下加入少量丙酮，加热回流4～5h，进行反应：

反应结束后，冷却、过滤，用少量5%的氢氧化钠稀溶液洗涤结晶，以除去双硫脲，再用少量水洗涤，用水-乙醇溶液进行重结晶提纯。

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硫代氨基脲海关

[ 海关编码 ]: 2930909059

[ 中文概述 ]:
2930909059 烯草酮、磺草酮、嗪草酸甲酯、磺草酮等〔包括苯氟磺胺、甲磺乐灵、氯硫酰草胺、脱叶磷〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
HS:2930909059 hydrazinecarbothioamide VAT:17.0% Tax rebate rate:9.0% Supervision conditions:S MFN tariff:6.5% General tariff:30.0%

硫代氨基脲文献

Carbamylation of immunoglobulin abrogates activation of the classical complement pathway.

Eur. J. Immunol. 44(11) , 3403-12, (2014)

Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily u...

Rhenium mixed-ligand complexes with S,N,S-tridentate thiosemicarbazone/thiosemicarbazide ligands.

Dalton Trans. 42(14) , 5111-21, (2013)

Rhenium(V) complexes containing tridentate thiosemicarbazones/thiosemicarbazides (H2L1) derived from N-[N′,N′-dialkylamino(thiocarbonyl)]benzimidoyl chlorides with 4,4-dialkylthiosemicarbazides have b...

Synthesis and antityrosinase mechanism of benzaldehyde thiosemicarbazones: novel tyrosinase inhibitors.

J. Agric. Food Chem. 60(6) , 1542-7, (2012)

p-Hydroxybenzaldehyde thiosemicarbazone (HBT) and p-methoxybenzaldehyde thiosemicarbazone (MBT) were synthesized and established by (1)H NMR and mass spectra. Both compounds were evaluated for their i...

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硫代氨基脲

硫代氨基脲用途

硫代氨基脲名称

硫代氨基脲生物活性

硫代氨基脲物理化学性质

硫代氨基脲MSDS

详细MSDS(安全技术说明书)

硫代氨基脲毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

硫代氨基脲安全信息

硫代氨基脲合成路线

详细合成路线

硫代氨基脲上下游产品

硫代氨基脲上游产品

硫代氨基脲下游产品

硫代氨基脲制备

硫代氨基脲海关

硫代氨基脲文献

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