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7,12-二甲基苯并[a]蒽

7,12-二甲基苯并[a]蒽用途

DMBA作为多环芳烃(PAH)具有致癌活性。DMBA用于在各种啮齿类动物模型中诱导肿瘤形成[1]。

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7,12-二甲基苯并[a]蒽名称

[ CAS 号 ]:
57-97-6

[ 中文名 ]:
7,12-二甲基苯并[a]蒽

[ 英文名 ]:
DMBA

[中文别名 ]:

[英文别名 ]:

EINECS 200-359-5
DMBA
7,12-Dimethyltetraphene
MFCD00003600
7,12-Dimethylbenzo[a]anthracene
Benz[a]anthracene, 7,12-dimethyl-
7,12-Dimethylbenz[a]anthracene

7,12-二甲基苯并[a]蒽生物活性

[ 描述 ]:

DMBA作为多环芳烃(PAH)具有致癌活性。DMBA用于在各种啮齿类动物模型中诱导肿瘤形成[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Csiszar A, Balasubramanian P, Tarantini S, Yabluchanskiy A, Zhang XA, Springo Z, Benbrook D, Sonntag WE, Ungvari Z. Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research. Geroscience. 2019 Apr;41(2):209-227.

7,12-二甲基苯并[a]蒽物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
463.5±15.0 °C at 760 mmHg

[ 熔点 ]:
122-123 °C(lit.)

[ 分子式 ]:
C₂₀H₁₆

[ 分子量 ]:
256.341

[ 闪点 ]:
227.3±14.5 °C

[ 精确质量 ]:
256.125214

[ LogP ]:
6.83

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.729

[ 储存条件 ]:
2-8°C

7,12-二甲基苯并[a]蒽MSDS

7,12-二甲基苯并[a]蒽安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H350-H370

[ 警示性声明 ]:
P201-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S53-S36/37-S45-S62-S61-S60

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DP4500000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

7,12-二甲基苯并[a]蒽合成路线

7,12-二甲基苯并[a]蒽上下游产品

7,12-二甲基苯并[a]蒽上游产品

7,12-二甲基苯并[a]蒽下游产品

7,12-二甲基苯并[a]蒽制备

1. 由9,10-二甲基-9,10-二羟基-9,10-二氢-1,2-苯并蒽或9,10-二甲基-9,10-二甲氧基-9,10-二氢-1,2-苯并蒽或9-甲基-1,2-苯并蒽-10-酮制备。

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7,12-二甲基苯并[a]蒽文献

The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells.

Chem. Biol. Interact. 221 , 70-6, (2014)

Licorice is derived from the rhizomes of Glycyrrhiza glabra. It has been used for confectioneries or culinary purposes. The rhizomes contain many flavonoidal compounds that have been shown to be biolo...

Core-shell nanoparticulate formulation of gemcitabine: lyophilization, stability studies, and in vivo evaluation.

Drug Deliv Transl Res 4 , 439-51, (2015)

Core-shell nanoparticulate formulation of gemcitabine was prepared by incorporating gemcitabine in a hydrophilic bovine serum albumin (BSA) core surrounded by hydrophobic poly(DL-lactic acid-co-glycol...

Ameliorative effect of mepenzolate bromide against pulmonary fibrosis.

J. Pharmacol. Exp. Ther. 350(1) , 79-88, (2014)

Idiopathic pulmonary fibrosis is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)-β1-induced i...

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