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4-羟基-7-三氟甲基-3-喹啉羧酸

4-羟基-7-三氟甲基-3-喹啉羧酸名称

[ CAS 号 ]:
574-92-5

[ 中文名 ]:
4-羟基-7-三氟甲基-3-喹啉羧酸

[ 英文名 ]:
4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid

[英文别名 ]:

MFCD00006771
EINECS 209-377-8
4-Hydroxy-7-trifluormethyl-chinolin-3-carbonsaeure
3-Carboxy-4-hydroxy-7-trifluoromethylquinoline.
BUTTPARK 219-48

4-羟基-7-三氟甲基-3-喹啉羧酸物理化学性质

[ 密度 ]:
1.55 g/cm3

[ 沸点 ]:
354.7ºC at 760 mmHg

[ 熔点 ]:
259-260 °C (dec.)(lit.)

[ 分子式 ]:
C₁₁H₆F₃NO₃

[ 分子量 ]:
257.16500

[ 闪点 ]:
168.3ºC

[ 精确质量 ]:
257.03000

[ PSA ]:
70.42000

[ LogP ]:
2.65740

[ 储存条件 ]:
室温，密闭，干燥

4-羟基-7-三氟甲基-3-喹啉羧酸MSDS

4-羟基-7-三氟甲基-3-喹啉羧酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB2188000

CHEMICAL NAME :: 3-Quinolinecarboxylic acid, 4-hydroxy-7-(trifluoromethyl)-

CAS REGISTRY NUMBER :: 574-92-5

BEILSTEIN REFERENCE NO. :: 0249406

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H6-F3-N-O3

MOLECULAR WEIGHT :: 257.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 9,585,1983

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4-羟基-7-三氟甲基-3-喹啉羧酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VB2188000

4-羟基-7-三氟甲基-3-喹啉羧酸合成路线

4-羟基-7-三氟甲基-3-喹啉羧酸上下游产品

4-羟基-7-三氟甲基-3-喹啉羧酸上游产品

4-羟基-7-三氟甲基-3-喹啉羧酸下游产品

4-羟基-7-三氟甲基-3-喹啉羧酸文献

Synthesis and testing of new antileukemic Schiff bases of N-hydroxy-N'-aminoguanidine against CCRF-CEM/0 human leukemia cells in vitro and synergism studies with cytarabine (Ara-C).

Pharm. Res. 10(4) , 515-20, (1993)

A series of eight new N-hydroxy-N'-aminoguanidine (HAG) Schiff bases [ArCH = NNHC(= NH)NHOH.tosylate] was synthesized as potential antitumor agents through the inhibition of the enzyme ribonucleotide ...

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