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间三氟甲苯胺

间三氟甲苯胺用途

主要用作医药、农药、染料中间体

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间三氟甲苯胺名称

[ CAS 号 ]:
98-16-8

[ 中文名 ]:
间氨基三氟甲苯

[ 英文名 ]:
3-(Trifluoromethyl)aniline

[中文别名 ]:

[英文别名 ]:

m-Aminobenztrifluoride
m-Aminobenzal fluoride
USAF ma-4
1-Amino-3-(trifluoromethyl)benzene
m-Trifluoromethylaniline
3-trifluoromethyl
2-NITRO-5-AMINO BENZOTRIFLUORIDE
1-amino-3-trifluoromethylbenzene
EINECS 206-884-6
MFCD00014717

间三氟甲苯胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
187.0±0.0 °C at 760 mmHg

[ 熔点 ]:
5 °C

[ 分子式 ]:
C₇H₆F₃N

[ 分子量 ]:
161.124

[ 闪点 ]:
85.0±0.0 °C

[ 精确质量 ]:
161.045227

[ PSA ]:
26.02000

[ LogP ]:
2.39

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
0.6±0.3 mmHg at 25°C

[ 折射率 ]:
1.478

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
5 g/L (20 ºC)

间三氟甲苯胺MSDS

间三氟甲苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XU9180000

CHEMICAL NAME :: m-Toluidine, alpha,alpha,alpha-trifluoro-

CAS REGISTRY NUMBER :: 98-16-8

BEILSTEIN REFERENCE NO. :: 0387672

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C7-H6-F3-N

MOLECULAR WEIGHT :: 161.14

WISWESSER LINE NOTATION :: ZR CXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,20,1982

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/m3/4H

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 10,131,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 14,118,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 10,131,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 690 mg/m3/2H

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 10,131,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 615 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,20,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 ug/m3/4H/22W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in chlorine Kidney, Ureter, Bladder - proteinuria

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 15(2),41,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993

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间三氟甲苯胺安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H312-H330-H373

[ 警示性声明 ]:
P260-P280-P284-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R21/22;R23;R33;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S45-S36/37/39-S28A

[ 危险品运输编码 ]:
UN 2948 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
XU9180000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29214300

间三氟甲苯胺合成路线

间三氟甲苯胺上下游产品

间三氟甲苯胺上游产品

间三氟甲苯胺下游产品

间三氟甲苯胺制备

1、间硝基三氟甲苯用铁粉还原：将盐酸及铁粉依次加入水中，加热至80℃，缓缓滴加间硝基三氟甲苯，控制在80-85℃加完，于1.5h内升温至回流，保温3h，冷却至50℃，加碳酸钠溶液（10%）1.7倍，蒸馏，馏出液分去水层，油状物用无水硫酸钠干燥后过滤，得间氨基三氟甲苯。收率85.7%。

2、其制备方法是在高压釜内依次加入间三氟甲基硝基苯、溶剂乙醇和催化剂，用氮气置换出釜内空气后开动搅拌，通入氢气，使釜内压力保持在0.1 MPa左右，温度控制在(100±5)℃，反应至不吸氢气为止，反应时间约1 h，通冷却水冷却，使釜内温度降至40℃以下，利用釜内余压出料，反应液过滤，除去催化剂，常压蒸去溶剂和水，减压蒸馏得成品。

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间三氟甲苯胺海关

[ 海关编码 ]: 2921420090

[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

间三氟甲苯胺文献

Synthesis, cytotoxicity and antimicrobial activity of thiourea derivatives incorporating 3-(trifluoromethyl)phenyl moiety.

Eur. J. Med. Chem. 101 , 111-25, (2015)

A total of 31 of thiourea derivatives was prepared reacting 3-(trifluoromethyl)aniline and commercial aliphatic and aromatic isothiocyanates. The yields varied from 35% to 82%. All compounds were eval...

A Mechanochromic Luminescent Dye Exhibiting On/Off Switching by Crystalline-Amorphous Transitions.

Chem. Asian J. 10 , 1698-702, (2015)

A mechanochromic luminescent dye based on a simple aminomaleimide skeleton was readily synthesized in a one-pot process. It exhibited an on/off mechanochromic luminescent switching property dependent ...

The many roles for fluorine in medicinal chemistry.

J. Med. Chem. 51 , 4359-69, (2008)

更多文献

间三氟甲苯胺

间三氟甲苯胺用途

间三氟甲苯胺名称

间三氟甲苯胺物理化学性质

间三氟甲苯胺MSDS

详细MSDS(安全技术说明书)

间三氟甲苯胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

间三氟甲苯胺安全信息

间三氟甲苯胺合成路线

详细合成路线

间三氟甲苯胺上下游产品

间三氟甲苯胺上游产品

间三氟甲苯胺下游产品

间三氟甲苯胺制备

间三氟甲苯胺海关

间三氟甲苯胺文献

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