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氢化可的松-17-戊酸酯

氢化可的松-17-戊酸酯用途

Hydrocortisone 17-valerate (Cortisol 17-valerate) 是噻唑烷类化合物。

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氢化可的松-17-戊酸酯名称

[ CAS 号 ]:
57524-89-7

[ 中文名 ]:
氢化可的松 17-戊酸酯

[ 英文名 ]:
Hydrocortisone Valerate

[中文别名 ]:

氢化可的松戊酸酯

[英文别名 ]:

CORTISOL 17-VALERATE
Flexicort
Westcort
HYDROCORTISONEVALERATE,USP
Hydrocortisone Valerate (200 mg)
cortisol valerate
hydrocortisone valerat
hydrocortisone-17-valerate
HYDROCORTISONE VALERATE

氢化可的松-17-戊酸酯生物活性

[ 描述 ]:

Hydrocortisone 17-valerate (Cortisol 17-valerate) 是噻唑烷类化合物。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Bodor N, et al. Soft drugs 4. 3-Spirothiazolidines of hydrocortisone and its derivatives[J]. International Journal of Pharmaceutics, 1982, 10(4): 307-321.

氢化可的松-17-戊酸酯物理化学性质

[ 密度 ]:
1.21g/cm3

[ 沸点 ]:
595.1ºC at 760mmHg

[ 熔点 ]:
217-220 °C

[ 分子式 ]:
C₂₆H₃₈O₆

[ 分子量 ]:
446.57600

[ 闪点 ]:
195ºC

[ 精确质量 ]:
446.26700

[ PSA ]:
100.90000

[ LogP ]:
3.52270

[ 外观性状 ]:
固体

[ 折射率 ]:
1.56

[ 储存条件 ]:
-20°C，惰性气体

氢化可的松-17-戊酸酯安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
40

[ 安全声明 (欧洲) ]:
22-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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氢化可的松-17-戊酸酯文献

Topical corticosteroid compounding: effects on physicochemical stability and skin penetration rate.

J. Am. Acad. Dermatol. 21(5 Pt 1) , 979-84, (1989)

Compounding compatibility studies of four corticosteroid cream products and four commonly added chemicals are presented. Physical alteration, chemical stability, micropreservative challenge status, an...

Addition of a topically applied corticosteroid to a modified Goeckerman regimen for treatment of psoriasis: effect on duration of remission.

J. Am. Acad. Dermatol. 13(5 Pt 1) , 784-91, (1985)

A double-blind parallel group study was undertaken to assess the effect of adding a topically applied corticosteroid cream to a modified Goeckerman regimen to treat patients with psoriasis. Nineteen p...

Temporal infiltration of leukocyte subsets into mouse skin inflamed with phorbol ester.

Agents Actions 37(3-4) , 260-7, (1992)

We have previously shown that multiple topical applications, over 11 days, of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a persistent inflammatory reaction characterized by e...

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