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8-氨基喹啉

8-氨基喹啉用途

用作医药中间体

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8-氨基喹啉名称

[ CAS 号 ]:
578-66-5

[ 中文名 ]:
8-氨基喹啉

[ 英文名 ]:
8-Aminoquinoline

[中文别名 ]:

[英文别名 ]:

8-Quinolinamine
MFCD00006809
quinolin-8-amine
EINECS 209-427-9
8-Aminoquinoline

8-氨基喹啉生物活性

[ 描述 ]:

8-氨基喹啉是一种生物化学试剂,可作为生物材料或有机化合物进行生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

8-氨基喹啉物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
289.8±0.0 °C at 760 mmHg

[ 熔点 ]:
62-65ºC

[ 分子式 ]:
C₉H₈N₂

[ 分子量 ]:
144.17

[ 闪点 ]:
171.5±8.1 °C

[ 精确质量 ]:
144.068741

[ PSA ]:
38.91000

[ LogP ]:
1.88

[ 外观性状 ]:
黄色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.708

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
slightly soluble

8-氨基喹啉MSDS

8-氨基喹啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA9627000

CHEMICAL NAME :: Quinoline, 8-amino-

CAS REGISTRY NUMBER :: 578-66-5

BEILSTEIN REFERENCE NO. :: 0114474

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C9-H8-N2

MOLECULAR WEIGHT :: 144.19

WISWESSER LINE NOTATION :: T66 BNJ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 480 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Leukocyte

DOSE/DURATION :: 100 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,285,1977

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8-氨基喹啉安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38;R68

[ 安全声明 (欧洲) ]:
S22-S26-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
VA9627000

[ 海关编码 ]:
29334990

8-氨基喹啉合成路线

8-氨基喹啉上下游产品

8-氨基喹啉上游产品

8-氨基喹啉下游产品

8-氨基喹啉海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

8-氨基喹啉文献

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine.

Malaria Journal 11 , 259, (2012)

The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale...

Aminoquinolines as fluorescent labels for hydrophilic interaction liquid chromatography of oligosaccharides.

Biol. Chem. 393(8) , 757-65, (2012)

In this study, we investigated the potential of four different aminoquinoline (AQ) compounds as fluorescent labels for glycan analysis using hydrophilic interaction liquid chromatography (HILIC) and f...

Copper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse model.

PLoS ONE 7(8) , e43105, (2012)

Alzheimer's disease (AD) is a neurodegenerative syndrom involving many different biological parameters, including the accumulation of copper metal ions in Aβ amyloid peptides due to a perturbation of ...

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