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硫酸异喹胍

硫酸异喹胍用途

去甲异丙脒半硫酸盐是一种TMPRSS2抑制剂,通过TMPRSS2依赖的方式抑制严重急性呼吸系统综合征冠状病毒2进入人类肺细胞系,IC50为22μM。半硫酸去甲异喹可用于抗病毒研究[1]。

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硫酸异喹胍名称

[ CAS 号 ]:
581-88-4

[ 中文名 ]:
硫酸异喹胍

[ 英文名 ]:
DEBRISOQUIN SULFATE

[英文别名 ]:

Debrisoquin hemisulfate
debrisoquine sulfate
Debrisoquin sulfate
debrisoquine sulphate

硫酸异喹胍生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

[ 靶点 ]

Human Endogenous Metabolite

硫酸异喹胍物理化学性质

[ 沸点 ]:
309.8ºC at 760 mmHg

[ 熔点 ]:
278-280°, 284-285° or 266-268° (H2O)

[ 分子式 ]:
C₁₀H₁₃N_3.1/₂H₂O₄S

[ 分子量 ]:
224.27

[ 闪点 ]:
141.1ºC

[ 精确质量 ]:
448.189270

[ PSA ]:
189.20000

[ LogP ]:
3.78020

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
H2O: 20 mg/mL with heat

硫酸异喹胍MSDS

详细MSDS(安全技术说明书)

硫酸异喹胍毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NW7010000

CAS REGISTRY NUMBER :: 581-88-4

LAST UPDATED :: 198804

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H13-N3.1/2H2-O4-S

MOLECULAR WEIGHT :: 224.30

WISWESSER LINE NOTATION :: T66 CNT&J CYZUM & 2WSQQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 610 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,129,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 235 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 132 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964

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硫酸异喹胍安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NW7010000

[ 海关编码 ]:
2933499090

硫酸异喹胍海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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