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醋酸诺美孕酮

醋酸诺美孕酮用途

Nomegestrol acetate 是一种有效的高选择性孕激素,可用作孕酮受体 (progesterone receptor) 的完全激动剂,与其他类固醇受体 (包括雄激素和糖皮质激素受体) 没有或具有很低的结合力。

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醋酸诺美孕酮名称

[ CAS 号 ]:
58652-20-3

[ 中文名 ]:
诺美孕酮醋酸酯

[ 英文名 ]:
Nomegestrol acetate

[中文别名 ]:

醋酸诺美孕酮

[英文别名 ]:

EINECS 261-379-8
Lutenyl
MFCD00941390
Nomegestrol acetate
19-normegestrol acetate

醋酸诺美孕酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 孕激素受体

研究领域 >> 内分泌

[ 靶点 ]

Progesterone receptor[1]

[参考文献]

[1]. Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76(6):531-9.

醋酸诺美孕酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
507.3±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₃H₃₀O₄

[ 分子量 ]:
370.482

[ 闪点 ]:
219.8±30.2 °C

[ 精确质量 ]:
370.214417

[ PSA ]:
60.44000

[ LogP ]:
3.34

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.554

[ 储存条件 ]:
2-8°C

醋酸诺美孕酮MSDS

详细MSDS(安全技术说明书)

醋酸诺美孕酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC8899200

CHEMICAL NAME :: 19-Norpregna-4,6-diene-3,20-dione, 17-alpha-hydroxy-6-methyl-, acetate

CAS REGISTRY NUMBER :: 58652-20-3

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C23-H30-O4

MOLECULAR WEIGHT :: 370.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1050 ug/kg/21D-I

TOXIC EFFECTS :: Endocrine - changes in luteinizing hormone Endocrine - estrogenic Endocrine - effect on menstrual cycle

REFERENCE :: BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year: 94,1199,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,710,1983

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醋酸诺美孕酮安全信息

[ 符号 ]:

GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361fd-H400

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
63-50

[ 安全声明 (欧洲) ]:
61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ RTECS号 ]:
RC8899200

醋酸诺美孕酮文献

Changing convention in combination oral contraceptives: estradiol and nomegestrol acetate in a monophasic 24/4 regimen.

J. Fam. Plann. Reprod. Health Care 39(3) , 211-6, (2013)

Initial oral contraceptive regimens were characterised by high doses of ethinylestradiol (EE) and a progestogen in a 21-day regimen that either included seven additional hormone-free tablets or simply...

A new contraceptive pill containing 17β-estradiol and nomegestrol acetate.

Womens. Health (Lond. Engl.) 9(1) , 13-23, (2013)

Most combined oral contraceptive pills contain ethinyl estradiol (EE) with progestins. In order to minimize the pill's cardiovascular risks, the concept of using 17β-estradiol (E2), the endogenous est...

The “newer” progestogens and postmenopausal hormone therapy (HRT)

J. Steroid Biochem. Mol. Biol. 142 , 48-51, (2014)

• The “newer” progestogens have a high bioavailability. • The “newer” progestogens have a sufficient progestogenic effect. • The “newer” progestogens do not cause undue side effects. • The “newer” pro...

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