l-3-hydroxy-n-methylmorphinan dihydrate

l-3-hydroxy-n-methylmorphinan dihydrate名称

[ CAS 号 ]:
5985-38-6

[ 英文名 ]:
l-3-hydroxy-n-methylmorphinan dihydrate

[英文别名 ]:

LEVORPHANOL TARTRATE SALT
LEVORPHANOL TARTRATE
levorphanol tartrate dihydrate
LEVORPHANOLTARTRATE,USP
levorphanol tartrate methanol solution
L-3-HYDROXY-N-METHYLMORPHINAN

l-3-hydroxy-n-methylmorphinan dihydrate物理化学性质

[ 沸点 ]:
410.4ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₃₃NO₉

[ 分子量 ]:
443.48800

[ 闪点 ]:
11ºC

[ 精确质量 ]:
443.21600

[ PSA ]:
156.99000

[ LogP ]:
0.76710

l-3-hydroxy-n-methylmorphinan dihydrate毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD1924200

CAS REGISTRY NUMBER :: 5985-38-6

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H23-N-O.C4-H6-O6.2H2-O

MOLECULAR WEIGHT :: 443.55

WISWESSER LINE NOTATION :: T6 G665/FP 2AF P FX ONT&TTJ IQ O1 &QVYQYQVQ &QH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 85,387,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 85,387,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 85,387,1951

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l-3-hydroxy-n-methylmorphinan dihydrate安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312 + H332-H317-H334-H360

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P201-P261-P280-P284-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T,F

[ 风险声明 (欧洲) ]:
R61

[ 安全声明 (欧洲) ]:
53-22-36/37-45-16-7

[ 危险品运输编码 ]:
UN 1544 6.1/PG 3

[ RTECS号 ]:
QD1924200

l-3-hydroxy-n-methylmorphinan dihydrate合成路线

详细合成路线

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l-3-hydroxy-n-methylmorphinan dihydrate文献

Sensitivity to the discriminative stimulus and antinociceptive effects of mu opioids: role of strain of rat, stimulus intensity, and intrinsic efficacy at the mu opioid receptor.

J. Pharmacol. Exp. Ther. 289 , 965, (1999)

Effects of low (butorphanol, nalbuphine)-, intermediate (buprenorphine)-, and high (morphine, levorphanol)-efficacy mu opioids were examined in F344, Sprague-Dawley (SD), Long-Evans (LE), and Lewis ra...

Characterization and distribution of a cloned rat mu-opioid receptor.

J. Neurochem. 64 , 14-24, (1995)

We have cloned and expressed a rat brain cDNA, TS11, that encodes a mu-opioid receptor based on pharmacological, physiological, and anatomical criteria. Membranes were prepared from COS-7 cells transi...

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