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D-氢化乳清酸

D-氢化乳清酸名称

[ CAS 号 ]:
5988-53-4

[ 中文名 ]:
D-二氢乳清酸 D-六氢-2,6-二氧-4-嘧啶羧酸

[ 英文名 ]:
D-Hydroorotic Acid

[中文别名 ]:

D-氢化乳清酸

[英文别名 ]:

Hydroorotic acid D-form
UNII-WXS4GY9Q24
D-4,5-dihydroorotic acid
MFCD01862150
Dihydro-D-orotic acid
R-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
Hydroorotic acid,D
4,5-dihydro-D-orotic acid
D-Hydroorotic acid

D-氢化乳清酸物理化学性质

[ 密度 ]:
1.523 g/cm3

[ 熔点 ]:
255ºC (dec.)(lit.)

[ 分子式 ]:
C₅H₆N₂O₄

[ 分子量 ]:
158.11200

[ 精确质量 ]:
158.03300

[ PSA ]:
95.50000

[ 储存条件 ]:
室温，干燥

D-氢化乳清酸MSDS

详细MSDS(安全技术说明书)

D-氢化乳清酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

D-氢化乳清酸文献

The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.

Biochemistry 47(34) , 8929-36, (2008)

Inhibitors of dihydroorotate dehydrogenase (DHODH) have been suggested for the treatment of rheumatoid arthritis, psoriasis, autoimmune diseases, Plasmodium, and bacterial and fungal infections. Here ...

Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.

Hum. Mol. Genet. 21(18) , 3969-83, (2012)

Biallelic mutations in the gene encoding DHOdehase [dihydroorotate dehydrogenase (DHODH)], an enzyme required for de novo pyrimidine biosynthesis, have been identified as the cause of Miller (Genée-We...

Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase fromToxoplasma gondii

Mol. Biochem. Parasitol. 184(2) , 71-81, (2012)

Graphical abstract Toxoplasma gondii dihydroorotate dehydrogenase is an essential mitochondrial enzyme that exhibits inhibitor sensitivities distinct from those of the human and Plasmodium falciparum ...

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