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氯美噻唑盐酸盐

氯美噻唑盐酸盐用途

Clomethiazole hydrochloride 是一种镇静剂和抗惊厥药。Clomethiazole hydrochloride 具有神经保护作用,可抑制 MDMA 诱导的血清素能神经末梢退化。

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氯美噻唑盐酸盐名称

[ CAS 号 ]:
6001-74-7

[ 中文名 ]:
盐酸氯美噻唑

[ 英文名 ]:
Chlormethiazole hydrochloride

[中文别名 ]:

[英文别名 ]:

Chlormethiazole hydrochloride

氯美噻唑盐酸盐生物活性

[ 描述 ]:

Clomethiazole hydrochloride 是一种镇静剂和抗惊厥药。Clomethiazole hydrochloride 具有神经保护作用,可抑制 MDMA 诱导的血清素能神经末梢退化。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Hewitt KE, et al. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. Neuropharmacology. 1994 Dec;33(12):1589-95.

[2]. Cross AJ, et al. The protective action of chlormethiazole against ischaemia-induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br J Pharmacol. 1995 Apr;114(8):1625-30.

氯美噻唑盐酸盐物理化学性质

[ 熔点 ]:
136 °C

[ 分子式 ]:
C₆H₉Cl₂NS

[ 分子量 ]:
297.52200

[ 精确质量 ]:
295.95200

[ PSA ]:
57.14000

[ LogP ]:
2.23800

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
水溶性：可溶；可溶于：醇

氯美噻唑盐酸盐MSDS

氯美噻唑盐酸盐安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H317-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-41-43

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934100090

氯美噻唑盐酸盐合成路线

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氯美噻唑盐酸盐下游产品

氯美噻唑盐酸盐海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

氯美噻唑盐酸盐文献

Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro.

J. Pharm. Pharmacol. 66(11) , 1534-51, (2014)

Naftopidil (NAF) is a chiral compound with two enantiomers (R(+)-NAF and S(-)-NAF) and is used as a racemic mixture in clinical practice. This study aims to investigate the metabolism of NAF enantiome...

Chlormethiazole: effectiveness against toxic effects of cocaine in mice.

J. Pharmacol. Exp. Ther. 295 , 153-161, (2000)

Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and e...

Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome.

Neurochem. Int. 43 , 155-164, (2003)

The serotonin (5-HT) syndrome is the most serious toxic interaction of antidepressants, but no pharmacotherapy has yet been established. In the present study, we created an animal model of the 5-HT sy...

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