3,8-二氨基-5-乙基-6-苯基菲啶氯化物
3,8-二氨基-5-乙基-6-苯基菲啶氯化物名称
[ CAS 号 ]:
602-52-8
[ 中文名 ]:
3,8-二氨基-5-乙基-6-苯基菲啶氯化物
[ 英文名 ]:
3,8-Diamino-5-ethyl-6-phenylphenanthridinium chl
[英文别名 ]:
- Novidium chloride
- homidium chloride
- Ethidium chloride
- Babidium chloride
- EINECS 210-018-2
- [3H]-Ethidium
3,8-二氨基-5-乙基-6-苯基菲啶氯化物物理化学性质
[ 分子式 ]:
C21H20ClN3
[ 分子量 ]:
349.85700
[ 精确质量 ]:
349.13500
[ PSA ]:
55.92000
[ LogP ]:
2.29820
3,8-二氨基-5-乙基-6-苯基菲啶氯化物毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SF7960000
- CHEMICAL NAME :
- Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl-, chloride
- CAS REGISTRY NUMBER :
- 602-52-8
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C21-H20-N3.Cl
- MOLECULAR WEIGHT :
- 349.89
- WISWESSER LINE NOTATION :
- T B666 HKJ EZ H2 IR& LZ &Q &G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56370 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 14 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 17640 ug/kg/28D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 17640 ug/kg/28D-I
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965
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