盐酸骆驼蓬酚

盐酸骆驼蓬酚用途

Harmalol hydrochloride 是一种 β-咔啉生物碱,存在于几种药用植物中,如Peganum harmala。Harmalol hydrochloride, Harmaline 的主要代谢产物,在转录和翻译后水平上显著抑制二恶英介导的 CYP1A1 诱导。Harmalol hydrochloride 具有抗氧化和清除羟自由基的特性。

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盐酸骆驼蓬酚名称

[ CAS 号 ]:
6028-07-5

[ 中文名 ]:
盐酸骆驼蓬酚

[ 英文名 ]:
Harmidol hydrochloride

[英文别名 ]:

harmalol dihydrochloride
HARMALOL HYDROCHLORIDE

盐酸骆驼蓬酚生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. El Gendy MA, et al. Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms. Food Chem Toxicol. 2012;50(2):353-362.

盐酸骆驼蓬酚物理化学性质

[ 沸点 ]:
507.5ºC at 760 mmHg

[ 熔点 ]:
265-268ºC (dec.)

[ 分子式 ]:
C₁₂H₁₃ClN₂O

[ 分子量 ]:
236.69700

[ 闪点 ]:
231ºC

[ 精确质量 ]:
236.07200

[ PSA ]:
48.38000

[ LogP ]:
2.47620

[ 储存条件 ]:
-20°C，密封，干燥

盐酸骆驼蓬酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1047000

CHEMICAL NAME :: 3H-Pyrido(3,4-b)indol-7-ol, 4,9-dihydro-1-methyl-, monohydrochloride

CAS REGISTRY NUMBER :: 6028-07-5

LAST UPDATED :: 198608

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H12-N2-O.Cl-H

MOLECULAR WEIGHT :: 236.72

WISWESSER LINE NOTATION :: T656 BM EN DUT&&J D1 LQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03207

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 3,218,1930

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盐酸骆驼蓬酚安全信息

[ 海关编码 ]:
2933990090

盐酸骆驼蓬酚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%