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D-葡糖二酸-1,4-内酯

D-葡糖二酸-1,4-内酯用途

β-葡萄糖醛酸酶抑制剂(β-IC4.50-强效)。与新型β-葡萄糖醛酸酶抑制剂相比,D-糖酸1,4-内酯水合物可以用作标准药物。D-糖酸1,4-内酯水合物具有抗癌、解毒和抗氧化特性[1][2]。

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D-葡糖二酸-1,4-内酯名称

[ CAS 号 ]:
61278-30-6

[ 中文名 ]:
D-葡糖二酸-1,4-内酯

[ 英文名 ]:
D-Saccharic acid 1,4-lactone hydrate

[中文别名 ]:

[英文别名 ]:

D-Saccharolactone
D-Saccharic acid 1,4-lactone monohydrate
D-Glucaro-1,4-lactone Monohydrate
1,4-Lactone-D-glucaric Acid Monohydrate
D-Glucaro-1,4-lacton
D-Glucaric acid-1,4-lactone
MFCD00149334

D-葡糖二酸-1,4-内酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Taha M, et al. Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs. Bioorg Chem. 2016;68:56-63.

[2]. Bhattacharya S, et al. Prophylactic role of D-Saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. J Biochem Mol Toxicol. 2011;25(6):341-354.

D-葡糖二酸-1,4-内酯物理化学性质

[ 熔点 ]:
80-82ºC

[ 分子式 ]:
C₆H₁₀O₈

[ 分子量 ]:
192.12400

[ 精确质量 ]:
192.02700

[ PSA ]:
124.29000

[ 储存条件 ]:
2-8°C

D-葡糖二酸-1,4-内酯MSDS

详细MSDS(安全技术说明书)

D-葡糖二酸-1,4-内酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932190090

D-葡糖二酸-1,4-内酯海关

[ 海关编码 ]: 2932190090

[ 中文概述 ]:
2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

D-葡糖二酸-1,4-内酯文献

Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.

Drug Metab. Dispos. 43(1) , 126-39, (2014)

Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investig...

A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors.

Curr. Chem. Genomics 5 , 13-20, (2011)

CPT-11 is a widely-used anti-cancer drug that is converted in vivo to its active metabolite, SN-38. In the liver, enzymes detoxify SN-38 by coupling it to a glucuronidate moiety and this inactive comp...

Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation.

Mol. Genet. Metab. 99(1) , 62-71, (2010)

Here we report the characterization of a knock-in mouse model for the autosomal recessive disorder mucopolysaccharidosis type I-Hurler (MPS I-H), also known as Hurler syndrome. MPS I-H is the most sev...

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