聚氧乙烯氢化蓖麻油

聚氧乙烯氢化蓖麻油用途

Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) 是聚乙二醇 (PEG) 与天然蓖麻油的混合物。Ethoxylated hydrogenated castor oil 可用于水包油 (o/w) 乳浊液的乳化和增溶。Ethoxylated hydrogenated castor oil 可以作为动物实验的助溶剂。

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聚氧乙烯氢化蓖麻油名称

[ CAS 号 ]:
61788-85-0

[ 中文名 ]:
聚氧乙烯氢化蓖麻油

[ 英文名 ]:
Ethoxylated hydrogenated castor oil

[中文别名 ]:

氟哌啶醇

[英文别名 ]:

Brotopon
Einalon S
Eukystol
Peluces
Haldol
Halosten
Linton
Aloperidin
Sigaperidol
haloperidol

聚氧乙烯氢化蓖麻油生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体内研究]

20%PEG-40氢化蓖麻油(10μl) 应用于鼠标左耳,右耳作为控件。观察6天小鼠胸腺发育情况,未观察到刺激迹象[1]。PEG-40氢化蓖麻油(尾静脉注射；300、900和2700毫克/千克；4周)用于短期毒性。PEG-40氢化蓖麻油在300和900 mg/kg剂量下无全身毒性。然而,在2700 mg/kg的剂量下,观察到轻微的共济失调,男性体重显著降低,女性体重略有降低[1]。以PEG-40氢化蓖麻油为表面活性剂,对空白纳米乳液进行了毒性研究,以负载多种活性化合物进行口服给药[2]。用近20%的PEG-40氢化蓖麻油将单油酸甘油酯(GMO)作为油乳化到水相中。在Webster小鼠中,给小鼠口服5000mg/kg空白纳米乳剂,每天一次,持续14天,这种纳米乳剂不会产生有害影响,并且对食物摄入没有影响[2]。

[参考文献]

[1]. PEG-40 HYDROGENATED CASTOR OIL

[2]. Heni Rachmawati, et al. The In Vitro-In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation. Sci Pharm. 2017 Mar 31;85(2):18. doi: 10.3390/scipharm85020018.

[3]. PEGylated Oils as Used in Cosmetics

聚氧乙烯氢化蓖麻油物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
529.0±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₁H₂₃ClFNO₂

[ 分子量 ]:
375.864

[ 闪点 ]:
273.8±30.1 °C

[ 精确质量 ]:
375.140137

[ LogP ]:
3.01

[ 外观性状 ]:
淡黄色油状糊状

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.581

[ 储存条件 ]:
室温

聚氧乙烯氢化蓖麻油安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

聚氧乙烯氢化蓖麻油文献

Formulation and biopharmaceutical evaluation of silymarin using SMEDDS.

Arch. Pharm. Res. 30(1) , 82-9, (2007)

Silymarin has been used to treat hepatobiliary diseases. However, it has a low bioavailability after being administered orally on account of its low solubility in water. In order to improve the dissol...

Preparation and evaluation of self-nanoemulsifying tablets of carvedilol.

AAPS PharmSciTech 10(1) , 183-92, (2009)

The purpose of this study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form emphasizing the excipients' effect on the development of...

Detailed molecular characterization of castor oil ethoxylates by liquid chromatography multistage mass spectrometry.

J. Chromatogr. A. 1218(40) , 7166-72, (2011)

The molecular characterization of castor oil ethoxylates (CASEOs) was studied by reverse-phase liquid chromatography (RPLC) mass spectrometry (MS) and multistage mass spectrometry (MS(n)). The develop...

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