2-氯-4-硝基酚
2-氯-4-硝基酚用途
用于有机合成
【用途二】
有机合成中间体。
2-氯-4-硝基酚名称
[ CAS 号 ]:
619-08-9
[ 中文名 ]:
2-氯-4-硝基苯酚
[ 英文名 ]:
2-Chloro-4-nitrophenol
[中文别名 ]:
[英文别名 ]:
- 2-Chloro-4-nitrophenol
- Phenol, 2-chloro-4-nitro-
- 3-Carboxybenzaldehyde
- EINECS 210-578-8
- MFCD00043910
- 2-Chlor-4-nitrobenzolol
2-氯-4-硝基酚物理化学性质
[ 密度 ]:
1.6±0.1 g/cm3
[ 沸点 ]:
290.6±25.0 °C at 760 mmHg
[ 熔点 ]:
106 °C
[ 分子式 ]:
C6H4ClNO3
[ 分子量 ]:
173.554
[ 闪点 ]:
129.6±23.2 °C
[ 精确质量 ]:
172.987976
[ PSA ]:
66.05000
[ LogP ]:
2.22
[ 外观性状 ]:
白色粉末或针状形态结晶
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.627
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运
[ 水溶解性 ]:
slightly soluble
2-氯-4-硝基酚MSDS
2-氯-4-硝基酚毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SK5075000
- CHEMICAL NAME :
- Phenol, 2-chloro-4-nitro-
- CAS REGISTRY NUMBER :
- 619-08-9
- BEILSTEIN REFERENCE NO. :
- 2046372
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C6-H4-Cl-N-O3
- MOLECULAR WEIGHT :
- 173.56
- WISWESSER LINE NOTATION :
- WNR DQ CG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570573
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,868,1975
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570573
2-氯-4-硝基酚安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H312-H315-H319-H332-H335
[ 警示性声明 ]:
P261-P280-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful;
[ 风险声明 (欧洲) ]:
R22;R36/37/38
[ 安全声明 (欧洲) ]:
S26-S36-S37/39
[ 危险品运输编码 ]:
2811
[ WGK德国 ]:
3
[ RTECS号 ]:
SK5075000
[ 海关编码 ]:
29089000
2-氯-4-硝基酚合成路线
2-氯-4-硝基酚上下游产品
2-氯-4-硝基酚上游产品
2-氯-4-硝基酚下游产品
2-氯-4-硝基酚制备
由对硝基酚经氯化而得。将对硝基酚和浓盐酸混合,加热溶解。冷却后慢慢加入氯酸钾水溶液,加毕搅拌半小时,放置过夜,过滤,用水洗去酸性即得粗品。粗品用80-90℃热水及少许乙酸溶解,脱色过滤,冷却,析出针状结晶即为成品。
2-氯-4-硝基酚海关
[ 海关编码 ]: 2908999090
[ 中文概述 ]:
2908999090 其他酚及酚醇的卤化等衍生物(包括其磺化、硝化或亚硝化衍生物). 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
2-氯-4-硝基酚文献
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An approach for optimization of epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors using truncated thienopyrimidine structures combined with enzymatic assay has been evaluated. This...
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[Combination of antimycotic preparations and natural proteinase inhibitors in otomycosis].Rev. Laryngol. Otol. Rhinol. (Bord.) 114(1) , 59-61, (1993)
In vitro experiments, Terrilytinum* increases the antimycotic activity of Clotrimazolum* and Nitrofungin*, and cancels out the inhibitory effect of Contrycal*. The combined application of Clotrimazolu...
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