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吗啡五水硫酸盐

吗啡五水硫酸盐名称

[ CAS 号 ]:
6211-15-0

[ 中文名 ]:
吗啡五水硫酸盐

[ 英文名 ]:
morphine sulfate pentahydrate

[中文别名 ]:

[英文别名 ]:

吗啡五水硫酸盐物理化学性质

[ 沸点 ]:
476.2ºC at 760 mmHg

[ 熔点 ]:
>240ºC (dec.)

[ 分子式 ]:
C34H50N2O15S

[ 分子量 ]:
758.83000

[ 闪点 ]:
241.8ºC

[ 精确质量 ]:
758.29300

[ PSA ]:
234.99000

[ LogP ]:
2.37850

[ 储存条件 ]:
Controlled Substance, -20°C Freezer

[ 水溶解性 ]:
ethanol: 1.8 mg/mL

吗啡五水硫酸盐MSDS

吗啡五水硫酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QC8760000
CAS REGISTRY NUMBER :
6211-15-0
LAST UPDATED :
199507
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C34-H38-N2-O6.H2-O4-S.5H2-O
MOLECULAR WEIGHT :
758.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
973 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,228,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,228,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7173 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1358 (estimated) No. of Female Employees: 956 (estimated)
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吗啡五水硫酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
22-36

[ 危险品运输编码 ]:
UN 1544 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
QC8760000

吗啡五水硫酸盐文献

Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis.

J. Pharmacol. Exp. Ther. 352(3) , 462-70, (2015)

Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug...

Catalytic enantioselective synthesis of quaternary carbon stereocentres.

Nature 516(7530) , 181-91, (2014)

Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catal...

Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery.

Br. J. Anaesth. 113(6) , 964-9, (2014)

Clonidine is a useful analgesic-sedative agent; however, few data exist regarding its use in infants after congenital heart disease surgery. We thus aimed to assess the absorption and safety of entera...


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