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O-去甲基美托洛尔

O-去甲基美托洛尔用途

O-Desmethyl metoprolol is the major active metabolite of the β1-adrenergic receptor blocker metoprolol.

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O-去甲基美托洛尔名称

[ CAS 号 ]:
62572-94-5

[ 中文名 ]:
O-去甲基美托洛尔

[ 英文名 ]:
O-Desmethyl Metoprolol

[英文别名 ]:

O-去甲基美托洛尔物理化学性质

[ 密度 ]:
1.085g/cm3

[ 沸点 ]:
424.6ºC at 760 mmHg

[ 熔点 ]:
70-72ºC

[ 分子式 ]:
C₁₄H₂₃NO₃

[ 分子量 ]:
253.33700

[ 闪点 ]:
210.6ºC

[ 精确质量 ]:
253.16800

[ PSA ]:
61.72000

[ LogP ]:
1.35000

[ 折射率 ]:
1.531

[ 储存条件 ]:
-20°C，密闭，干燥

O-去甲基美托洛尔毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA0512150

CHEMICAL NAME :: Benzeneethanol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-

CAS REGISTRY NUMBER :: 62572-94-5

LAST UPDATED :: 198809

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H23-N-O3

MOLECULAR WEIGHT :: 253.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,186,1979

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O-去甲基美托洛尔安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DA0512150

O-去甲基美托洛尔文献

Identification of transformation products from β-blocking agents formed in wetland microcosms using LC-Q-ToF.

J. Mass Spectrom. 51 , 207-18, (2016)

Identification of degradation products from trace organic compounds, which may retain the biological activity of the parent compound, is an important step in understanding the long-term effects of the...

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