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1,6-二溴己烷

1,6-二溴己烷用途

【用途一】
用作农药、医药中间体
【用途二】
有机合成中间体，用于降血压药六甲溴胺的生产。

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1,6-二溴己烷名称

[ CAS 号 ]:
629-03-8

[ 中文名 ]:
1,6-二溴己烷

[ 英文名 ]:
1,6-Dibromohexane

[中文别名 ]:

[英文别名 ]:

1,6-Dibromohexane
Hexane, 1,6-dibromo-
MFCD00000272
hexamethylene dibromide
HEXANE,1,6-DIBROMO
1,6-bis(bromo)hexane
Hexamethylene Bromide
1,6-dibromohexamethylene
1,6-Dibromohexan
1,6-Dibromo-n-hexane

1,6-二溴己烷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
244.1±8.0 °C at 760 mmHg

[ 熔点 ]:
−2-2.5 °C(lit.)

[ 分子式 ]:
C₆H₁₂Br₂

[ 分子量 ]:
243.967

[ 闪点 ]:
110.8±17.7 °C

[ 精确质量 ]:
241.930557

[ LogP ]:
3.67

[ 外观性状 ]:
无色或淡黄色液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.500

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
insoluble

1,6-二溴己烷MSDS

1,6-二溴己烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MO1515000

CHEMICAL NAME :: Hexane, 1,6-dibromo-

CAS REGISTRY NUMBER :: 629-03-8

BEILSTEIN REFERENCE NO. :: 1236322

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H12-Br2

MOLECULAR WEIGHT :: 244.00

WISWESSER LINE NOTATION :: E6E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 umol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 141,11,1984

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1,6-二溴己烷安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H317

[ 警示性声明 ]:
P264-P280-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25;R51/53

[ 安全声明 (欧洲) ]:
S36-S45-S61

[ 危险品运输编码 ]:
UN 2810 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
MO1515000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2903299090

1,6-二溴己烷合成路线

1,6-二溴己烷上下游产品

1,6-二溴己烷上游产品

1,6-二溴己烷下游产品

1,6-二溴己烷制备

1.由己二醇经溴化而得：在500mL带回流冷凝器的烧瓶中,加入58g1,6-己二醇和6.84g红磷。搅拌加热到100~150℃,滴加80g溴。加完后继续在该室温下搅拌1h。将反应物冷至室温,用水冲稀。加入100mL乙醚
,滤除过量的红磷。分出二溴化物的乙醚溶液,依次用10%硫酸钠溶液和水洗涤。以无水氯化钙干燥。蒸除乙醚后,减压蒸馏,收集114~115℃(1.6kPa)馏分,得成品85g,产率为71%。

2.制法：

于装有搅拌器、温度计、回流冷凝器、滴液漏斗的反应瓶中，加入1,6-己二醇(2)59g(0.5mol),红磷6.84g，搅拌下慢慢加入至100～150℃，滴加溴素80g(0.5mol)，加完后继续于此温度范围反应1h。冷却至室温，倒入冷水中，滤去未反应的红磷。用乙醚提取三次，合并乙醚溶液，依次用10%的硫代硫酸钠、水洗涤，无水氯化钙干燥。蒸出乙醚后，减压蒸馏，收集114～115℃/1.6kPa的馏分，得1,6-二溴己烷(1)85g,收率71%。

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1,6-二溴己烷海关

[ 海关编码 ]: 2903299090

[ 中文概述 ]:
HS: 2903299090. 其他无环烃的不饱和氯化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903299090 other unsaturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

1,6-二溴己烷文献

Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles.

AAPS J. 17(1) , 256-67, (2015)

Carbohydrate functionalization of nanoparticles allows for targeting of C-type lectin receptors. This family of pattern recognition receptors expressed on innate immune cells, such as macrophages and ...

Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity.

Int. J. Nanomedicine 10 , 229-43, (2015)

H5N1 avian influenza is a significant global concern with the potential to become the next pandemic threat. Recombinant subunit vaccines are an attractive alternative for pandemic vaccines compared to...

Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms.

PLoS Negl. Trop. Dis. 9 , e0004173, (2015)

Filarial diseases represent a significant social and economic burden to over 120 million people worldwide and are caused by endoparasites that require the presence of symbiotic bacteria of the genus W...

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1,6-二溴己烷

1,6-二溴己烷用途

1,6-二溴己烷名称

1,6-二溴己烷物理化学性质

1,6-二溴己烷MSDS

详细MSDS(安全技术说明书)

1,6-二溴己烷毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,6-二溴己烷安全信息

1,6-二溴己烷合成路线

详细合成路线

1,6-二溴己烷上下游产品

1,6-二溴己烷上游产品

1,6-二溴己烷下游产品

1,6-二溴己烷制备

1,6-二溴己烷海关

1,6-二溴己烷文献

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