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2,5-二羟基肉桂酸甲酯

2,5-二羟基肉桂酸甲酯用途

2,5-二羟基肉桂酸甲酯是一种erbstatin类似物,是一种稳定、有效的EGFR激酶活性抑制剂[1]。

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2,5-二羟基肉桂酸甲酯名称

[ CAS 号 ]:
63177-57-1

[ 中文名 ]:
2,5-二羟基肉桂酸甲酯

[ 英文名 ]:
Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate

[中文别名 ]:

甲基2,5-二HYR氧基肉桂酸酯

[英文别名 ]:

Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate
MFCD00132932
methyl (E)-3-(2,5-dihydroxyphenyl)prop-2-enoate

2,5-二羟基肉桂酸甲酯生物活性

[ 描述 ]:

2,5-二羟基肉桂酸甲酯是一种erbstatin类似物,是一种稳定、有效的EGFR激酶活性抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> JAK/STAT信号通路 >> EGFR

信号通路 >> 蛋白酪氨酸激酶 >> EGFR

[参考文献]

[1]. Umezawa K, et al. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett. 1990 Jan 29;260(2):198-200.

2,5-二羟基肉桂酸甲酯物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
400.7±35.0 °C at 760 mmHg

[ 熔点 ]:
178-180°C

[ 分子式 ]:
C₁₀H₁₀O₄

[ 分子量 ]:
194.184

[ 闪点 ]:
163.3±19.4 °C

[ 精确质量 ]:
194.057907

[ PSA ]:
66.76000

[ LogP ]:
1.51

[ 外观性状 ]:
结晶

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.629

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
0.1 M NaOH: soluble

2,5-二羟基肉桂酸甲酯MSDS

详细MSDS(安全技术说明书)

2,5-二羟基肉桂酸甲酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S22-S26-S36-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

2,5-二羟基肉桂酸甲酯文献

Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors.

Biochemistry 40(3) , 777-90, (2001)

The facilitative hexose transporter GLUT1 is a multifunctional protein that transports hexoses and dehydroascorbic acid, the oxidized form of vitamin C, and interacts with several molecules structural...

Mechanism of topoisomerase II inhibition by staurosporine and other protein kinase inhibitors.

J. Biol. Chem. 271(42) , 26418-23, (1996)

Topoisomerase II is an essential enzyme for proliferation of eukaryotic cells. It is also a target for many antineoplastic drugs that promote stabilization of covalent complexes between topoisomerase ...

Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells.

Bone 23(1) , 17-26, (1998)

This investigation examined which signal pathways are of relevance in growth factor-stimulated bone cell mitogenesis. Platelet-derived growth factor (PDGF) and insulin-like growth factor-II (IGF-II) w...

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