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虎红钠盐

虎红钠盐用途

用作吸附指示剂

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虎红钠盐名称

[ CAS 号 ]:
632-69-9

[ 中文名 ]:
孟加拉玫瑰红

[ 英文名 ]:
Rose Bengal sodium

[中文别名 ]:

[英文别名 ]:

MFCD00151169
Food Red No. 105
LTE4 ELISA
r105sodium
LTD4 ELISA
Bengal Rose
MDC ELISA
UNII:956575SN5L
LTB4 ELISA
LTC4 ELISA

虎红钠盐生物活性

[ 描述 ]:

Rose Bengal sodium 是一种深红色的染料,它是一种合成的荧光素衍生物,主要成分是 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo 荧光素。Rose Bengal sodium 被广泛用作眼科诊断剂,它可以检测眼表干燥或受损的细胞,并具有抗病毒活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

研究领域 >> 其他

[参考文献]

[1]. Doughty MJ, et, al. Fluorescence characteristics of sodium fluorescein-rose bengal ophthalmic solution mixtures. Cont Lens Anterior Eye. 2014 Oct; 37(5): 358-62.

[2]. Roat MI, et, al. The antiviral effects of rose bengal and fluorescein. Arch Ophthalmol. 1987 Oct; 105(10): 1415-7.

虎红钠盐物理化学性质

[ 沸点 ]:
757.8ºC at 760 mmHg

[ 熔点 ]:
>300°C

[ 分子式 ]:
C₂₀H₂Cl₄I₄Na₂O₅

[ 分子量 ]:
1017.636

[ 闪点 ]:
412.1ºC

[ 精确质量 ]:
1015.463013

[ PSA ]:
93.40000

[ LogP ]:
8.10410

[ 外观性状 ]:
紫红色固体

[ 储存条件 ]:
避免光

[ 水溶解性 ]:
soluble

虎红钠盐MSDS

虎红钠盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LM5920000

CHEMICAL NAME :: Fluorescein, 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-, disodium salt

CAS REGISTRY NUMBER :: 632-69-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H2-Cl4-I4-O5.2Na

MOLECULAR WEIGHT :: 1017.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 707 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors

REFERENCE :: JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 77,277,1986 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 650 mg/kg

SEX/DURATION :: female 8-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,391,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 400 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,391,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 gm/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,391,1982

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虎红钠盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S22-S24/25-S37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LM5920000

虎红钠盐合成路线

虎红钠盐上下游产品

虎红钠盐上游产品

虎红钠盐下游产品

虎红钠盐制备

方法一、重组TNFα的工艺过程
细菌发酵将工程菌接种于LB培养基，37℃震荡培养至A600nm=1，转至M9培养基，于42℃诱导4h。离心，收集菌体。用pH为8的磷酸盐缓冲液(PB，10mmol/L)悬浮菌体，并用超声破碎菌体，离心收集上清液，对PB透析，得TNFα粗品。
工程菌[培养、发酵]→[37℃、42℃]发酵菌体[10mmol/L PB]→[pH8]TNFα粗品
DEAE-Sepharose FF 离子交换柱层析离子交换柱用PB平衡，加TNFα粗品，用PB洗柱，再加75 mmol/L NaCl洗脱，收集各峰，测TNFα活性。
TNFα粗品[DEAE-Sepharose FF离子柱]→[75 mmol/L NaCl]TNFα活性组分I
Q-Sepharose FF离子交换柱层析离子交换柱用pH 8、20 mmol/LTris-HCl缓冲液平衡，然后加TNFα活性组分I，用80 mmol/L NaCl洗脱，收集各峰，测TNFα活性，得TNFα活性组分II。
TNFα活性组分I[Q-Sepharose FF离子柱]→[80 mmol/L NaCl]TNFα活性组分II
CM-Sepharose FF离子交换柱层析离子交换柱用pH为6的10mmol/L PB平衡，加TNFα活性组分II，再依次用该PB液、PB液加200mmol/L NaCl及PB液加600 mmol/L NaCl分步洗脱，收集各洗脱液，测TNFα活性，即得TNFα纯品(在4℃时，通过三次常压离子交换，电泳表明：PB液加600 mmol/L NaCl的洗脱峰为TNFα单一条带，可得TNFα纯品)。
TNFα活性组分II[CM-Sepharose FF离子柱]→[PB、200及600mmol/L NaCl]TNFα纯品
方法二、对合成的TNFα突变改造
突变改造用多位点突变引物和PCR方法对合成的TNFα基因突变改造，使其第二位精氨酸密码子CGT变为赖氨酸密码子AAA，即得突变基因TNF-K2。
TNFα基因[多位点突变引物、PCR方法]→TNF-K2
转化、重组将TNF-K2插入载体pSB-92的PL启动子下游，转化E．coliJM103，经酶切鉴定筛选转化子，得重组质粒pSB-TNF-K2。TNF-K2[pSB-92]→pSB-TNF-K2
培养、诱导将pSB-TNF-K2于30℃培养至对数生长期，于42℃诱导4h，即得突变体[Lys2]TNFα，其分子量为17kD，比活性为6.8×107U/mg 蛋白，是一种可溶性蛋白质。
pSB-TNF-K2[30℃, 42℃, 4h]→[Lys2]TNFα.

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虎红钠盐文献

Rescue of cortical neurovascular functions during the hyperacute phase of ischemia by peripheral sensory stimulation.

Neurobiol. Dis. 75 , 53-63, (2015)

To investigate the potential therapeutic effects of peripheral sensory stimulation during the hyperacute phase of stroke, the present study utilized electrophysiology and photoacoustic imaging techniq...

The promoting effects of food dyes, erythrosine (Red 3) and rose bengal B (Red 105), on thyroid tumors in partially thyroidectomized N-bis(2-hydroxypropyl)-nitrosamine-treated rats.

Jpn. J. Cancer Res. 79(3) , 314-9, (1988)

The effects of erythrosine (Red 3), rose bengal B (Red 105) and thyroidectomy on the development of thyroid tumor were examined in male Wistar rats treated with N-bis(2-hydroxypropyl)nitrosamine (DHPN...

[A laboratory method for sensitized isomerization of polyene macrolides].

Antibiot. Khimioter. 41(2) , 16-21, (1996)

The study was aimed at the development of a laboratory procedure for isomerization of polyene macrolides in the presence of sensitizers. The reaction was performed with exposure of levorin solutions t...

更多文献

虎红钠盐

虎红钠盐用途

虎红钠盐名称

虎红钠盐生物活性

虎红钠盐物理化学性质

虎红钠盐MSDS

详细MSDS(安全技术说明书)

虎红钠盐毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

虎红钠盐安全信息

虎红钠盐合成路线

详细合成路线

虎红钠盐上下游产品

虎红钠盐上游产品

虎红钠盐下游产品

虎红钠盐制备

虎红钠盐文献

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