L-α-羟基戊二酸二钠盐

L-α-羟基戊二酸二钠盐用途

L-2-Hydroxyglutaric acid disodium 是一种表观遗传修饰因子,可用于肾癌治疗。L-2-Hydroxyglutaric acid disodium 可抑制组蛋白去甲基化酶 (histone demethylases),从而促进组蛋白甲基化。L-2-Hydroxyglutaric acid 抑制线粒体肌酸激酶 (Mi-CK) 活性,Km 和 Ki 分别为 2.52 mM 和11.13 mM。

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L-α-羟基戊二酸二钠盐名称

[ CAS 号 ]:
63512-50-5

[ 中文名 ]:
S-2-羟基戊二酸

[ 英文名 ]:
L-2-Hydroxyglutaric acid disodium

[中文别名 ]:

L-2-羟基戊二酸二钠

[英文别名 ]:

Pentanedioic acid, 2-hydroxy-, sodium salt (1:2)
(2S)-2-Hydroxyglutaric Acid Disodium Salt
Disodium 2-hydroxypentanedioate

L-α-羟基戊二酸二钠盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 表观遗传学 >> 组蛋白去甲基化酶

[体外研究]

L-2-羟基戊二酸能有效抑制2-氧戊二酸(2-OG)依赖性双加氧酶(2OGDs),包括10-11转位(TET)酶[1]。

[参考文献]

[1]. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.

[2]. da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24.

L-α-羟基戊二酸二钠盐物理化学性质

[ 熔点 ]:
>300ºC

[ 分子式 ]:
C₅H₆Na₂O₅

[ 分子量 ]:
192.078

[ 精确质量 ]:
192.001068

[ PSA ]:
100.49000

[ 储存条件 ]:
−20°C

L-α-羟基戊二酸二钠盐MSDS

详细MSDS(安全技术说明书)

L-α-羟基戊二酸二钠盐安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

L-α-羟基戊二酸二钠盐文献

Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues.

Anal. Biochem. 459 , 1-11, (2014)

Hypoxia-inducible factor-1 alpha (HIF-1α) is an important marker of hypoxia in human tumors and has been implicated in tumor progression. Drugs targeting HIF-1α are being developed, but the ability to...

Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.

Proc. Natl. Acad. Sci. U. S. A. 110(42) , 17017-22, (2013)

The 2-hydroxyglutarate (2-HG) has been reported to result from mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes and to function as an "oncometabolite." To evaluate the clinical sign...

Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.

J. Clin. Oncol. 32(4) , 297-305, (2014)

Mutated isocitrate dehydrogenases (IDHs) 1 and 2 produce high levels of 2-hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML), serum 2-HG would predict the presence of ID...

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