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4α-佛波醇12-十四酸酯13-乙酸酯

4α-佛波醇12-十四酸酯13-乙酸酯用途

4α-TPA是TPA的一种非活性形式,用作TPA激活事件的阴性对照[1]。

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4α-佛波醇12-十四酸酯13-乙酸酯名称

[ CAS 号 ]:
63597-44-4

[ 中文名 ]:
4-Alpha-佛波醇-12-豆蔻酸-13-乙酸

[ 英文名 ]:
4α-TPA

[英文别名 ]:

-yl ester
4-alpha-PMA
MFCD00153860

4α-佛波醇12-十四酸酯13-乙酸酯生物活性

[ 描述 ]:

4α-TPA是TPA的一种非活性形式,用作TPA激活事件的阴性对照[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

TPA(5、50和100 ng/ml；24小时),而不是4α-TPA,在U87细胞中诱导MMP-9酶活性(MMP-9酶)和mRNA表达(MMP-9 mRNA)[1]。

[参考文献]

[1]. Chiu WT, et al. Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation. Neurobiol Dis. 2010;37(1):118-129.

4α-佛波醇12-十四酸酯13-乙酸酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
698.1±55.0 °C at 760 mmHg

[ 分子式 ]:
C₃₆H₅₆O₈

[ 分子量 ]:
616.83

[ 闪点 ]:
208.1±25.0 °C

[ 精确质量 ]:
616.397522

[ PSA ]:
130.36000

[ LogP ]:
7.71

[ 外观性状 ]:
灰白色至黄色粉末

[ 蒸汽压 ]:
0.0±5.0 mmHg at 25°C

[ 折射率 ]:
1.553

[ 储存条件 ]:
-20°C，密封，干燥

4α-佛波醇12-十四酸酯13-乙酸酯MSDS

详细MSDS(安全技术说明书)

4α-佛波醇12-十四酸酯13-乙酸酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

4α-佛波醇12-十四酸酯13-乙酸酯文献

Differential cellular uptake and metabolism of curcuminoids in monocytes/macrophages: regulatory effects on lipid accumulation.

Br. J. Nutr. 112(1) , 8-14, (2014)

We have previously shown that curcumin (CUR) may increase lipid accumulation in cultured human acute monocytic leukaemia cell line THP-1 monocytes/macrophages, but that tetrahydrocurcumin (THC), an in...

Protein kinase C-activating tumor promoters modulate the DNA damage response in UVC-irradiated TK6 cells.

Toxicol. Lett. 229(1) , 210-9, (2014)

12-O-Tetradecanoylphorbol-13-acetate (TPA) is a non-genotoxic tumor promoter that dysregulates the protein kinase C (PKC) pathway and causes variable cellular responses to DNA damage in different expe...

Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.

Mol. Carcinog. 54(2) , 134-47, (2015)

Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T ce...

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