Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
名称
[ CAS 号 ]:
63989-75-3
[ 英文名 ]:
Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
[英文别名 ]:
- N-Benzoyltrimethylcolchicinsaeuremethylaether
- N-Benzoyl-deacetylcolchicine
- Colchicine,N-benzoyl-N-deacetyl
- N-Benzoyl trimethyl colchicinic acid methyl ether
- N-Benzoyl tmca methyl ether
- COLCHICINE,N-DEACETYL-N-BENZOYL
- N-benzoyl-N-deacetylcolchicine
物理化学性质
[ 密度 ]:
1.28g/cm3
[ 沸点 ]:
780.3ºC at 760 mmHg
[ 分子式 ]:
C27H27NO6
[ 分子量 ]:
461.50600
[ 闪点 ]:
425.7ºC
[ 精确质量 ]:
461.18400
[ PSA ]:
83.09000
[ LogP ]:
4.55640
[ 折射率 ]:
1.62
[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0790000
- CHEMICAL NAME :
- Colchicine, N-deacetyl-N-benzoyl-
- CAS REGISTRY NUMBER :
- 63989-75-3
- BEILSTEIN REFERENCE NO. :
- 3184511
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C27-H27-N-O6
- MOLECULAR WEIGHT :
- 461.55
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JMVR& NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27924 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 12500 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Gastrointestinal - other changes
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- REFERENCE :
- CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950
合成路线
上下游产品
上游产品
下游产品
推荐生产厂家/供应商：
暂无推荐供应商。请联系客服获知如何成为推荐供应商。
热门化合物
CAS号[63989-75-3]化源网提供[Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版：Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
标题：63989-75-3_CAS号:63989-75-3_Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- - 化源网 地址：https://m.chemsrc.com/mip/cas/63989-75-3_901028.html