Trimethylcolchicinic acid methyl ether

Trimethylcolchicinic acid methyl ether用途

Trimethylcolchicinic acid methyl ether, Antimitotic agent that intercepts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal.

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Trimethylcolchicinic acid methyl ether名称

[ CAS 号 ]:
3476-50-4

[ 英文名 ]:
Trimethylcolchicinic acid methyl ether

[英文别名 ]:

N-deacethylcolchicine
N-deacetylcolchicine
trimethylcolchicinic acid methyl ether
deacetylcolchicine
Desacetylcolchicine

Trimethylcolchicinic acid methyl ether物理化学性质

[ 密度 ]:
1.25g/cm3

[ 沸点 ]:
626.6ºC at 760mmHg

[ 分子式 ]:
C₂₀H₂₃NO₅

[ 分子量 ]:
357.40000

[ 闪点 ]:
287ºC

[ 精确质量 ]:
357.15800

[ PSA ]:
80.01000

[ LogP ]:
3.39450

[ 折射率 ]:
1.597

Trimethylcolchicinic acid methyl ether毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0785000

CHEMICAL NAME :: Colchicine, N-deacetyl-

CAS REGISTRY NUMBER :: 3476-50-4

BEILSTEIN REFERENCE NO. :: 2822162

LAST UPDATED :: 199707

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C20-H23-N-O5

MOLECULAR WEIGHT :: 357.44

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JZ NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 49 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

REFERENCE :: CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950

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Trimethylcolchicinic acid methyl ether安全信息

[ WGK德国 ]:
3

[ 海关编码 ]:
2922509090

Trimethylcolchicinic acid methyl ether合成路线

详细合成路线

Trimethylcolchicinic acid methyl ether上下游产品

Trimethylcolchicinic acid methyl ether上游产品

Trimethylcolchicinic acid methyl ether下游产品

Trimethylcolchicinic acid methyl ether海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%