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21-脱氧皮质醇

21-脱氧皮质醇用途

21脱氧皮质醇是一种内源性代谢产物。21脱氧皮质素是先天性肾上腺增生的标志[1]。

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21-脱氧皮质醇名称

[ CAS 号 ]:
641-77-0

[ 中文名 ]:
11beta,17alpha-二羟基-4-孕烯-3,20-二酮

[ 英文名 ]:
11beta,17alpha-dihydroxy-4-pregnene-3,20-dione

[英文别名 ]:

21-deoxycortisol
21-Deoxyhydrocortisone
21-Dehydrohydrocortisone
21-DESOXYCORTISOL
21 DEOXYCORTISOL 21-DESOXYCORTISOL
4-pregnene-11-B-17-A-diol-3-20-dione
4-Pregnen-11,17a-diol-3,20-dione-d8
EINECS 211-375-7

21-脱氧皮质醇生物活性

[ 描述 ]:

21脱氧皮质醇是一种内源性代谢产物。21脱氧皮质素是先天性肾上腺增生的标志[1]。

[ 相关类别 ]:

研究领域 >> 内分泌

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Franks RC. Plasma 17-hydroxyprogesterone, 21-deoxycortisol and cortisol in congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1974;39(6):1099-1102.

21-脱氧皮质醇物理化学性质

[ 密度 ]:
1.21g/cm3

[ 沸点 ]:
523.9ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₃₀O₄

[ 分子量 ]:
346.46100

[ 闪点 ]:
284.7ºC

[ 精确质量 ]:
346.21400

[ PSA ]:
74.60000

[ LogP ]:
2.80920

[ 折射率 ]:
1.576

[ 储存条件 ]:
?20°C

21-脱氧皮质醇安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
7-16-36/37-45

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

21-脱氧皮质醇合成路线

详细合成路线

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21-脱氧皮质醇文献

An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.

J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015)

Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M...

Hirsutism and acne in women: coordinated radioimmunoassays for eight relevant plasma steroids.

Clin. Chem. 40(12) , 2296-305, (1994)

We developed and validated a coordinated set of RIAs for the following eight steroids in single small aliquots (< or = 1 mL) of plasma: androstenedione, dehydroepiandrosterone, 11-deoxycortisol, 21-de...

Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency.

Clin. Endocrinol. (Oxf.) 73(6) , 700-6, (2010)

Congenital adrenal hyperplasia caused by classic 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder with a high prevalence of asymptomatic heterozygote carriers (HTZ) in the general ...

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