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N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸

N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸用途

Chrysame G是刚果红的羧酸类似物,可以用作阿尔茨海默病淀粉样蛋白沉积的探针。蚕蛹G还可以抑制Aβ诱导的PC12细胞毒性[1][2]。

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N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸名称

[ CAS 号 ]:
6472-91-9

[ 中文名 ]:
N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸

[ 英文名 ]:
CHRYSAMINE G

[中文别名 ]:

金胺 G

[英文别名 ]:

C.I.Direct Yellow 1
Chrysamin-G
CHRYSAMINE

N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸生物活性

[ 描述 ]:

Chrysame G是刚果红的羧酸类似物,可以用作阿尔茨海默病淀粉样蛋白沉积的探针。蚕蛹G还可以抑制Aβ诱导的PC12细胞毒性[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Klunk WE, et, al. Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe. Neurobiol Aging. Jul-Aug 1995;16(4):541-8.

[2]. Klunk WE, et, al. Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Life Sci. 1998;63(20):1807-14.

N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸物理化学性质

[ 沸点 ]:
711.3ºC at 760 mmHg

[ 分子式 ]:
C₂₆H₁₆N₄Na₂O₆

[ 分子量 ]:
526.40800

[ 闪点 ]:
384ºC

[ 精确质量 ]:
526.08700

[ PSA ]:
170.16000

[ LogP ]:
4.32260

[ 储存条件 ]:
-20°C，密闭，干燥

N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸MSDS

N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸合成路线

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N-芴甲氧羰基-D-1,2,3,4-四氢异喹啉-3-羧酸文献

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.

J. Neuropathol. Exp. Neurol. 61 , 797-805, (2002)

The identification of amyloid deposits in living Alzheimer disease (AD) patients is important for both early diagnosis and for monitoring the efficacy of newly developed anti-amyloid therapies. Methox...

Amyloid binding ligands as Alzheimer's disease therapies.

Neurobiol. Aging 23 , 1039-1042, (2002)

Extracellular senile plaques (SPs) are hallmark brain lesions of sporadic Alzheimer's disease (AD) and the likely consequence of genetic mutations that cause familial AD by increasing production of am...

Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice.

Neurosci. Lett. 333 , 5-8, (2002)

The neurotoxicity of amyloid beta (Abeta) is widely believed to play a seminal role in neurodegeneration in Alzheimer's disease. We examined the effect of Chrysamine G (CG) on such neurotoxicity using...

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