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2-(1,8-萘啶-2-基)苯酚

2-(1,8-萘啶-2-基)苯酚用途

2-NP是STAT1转录的选择性增强子。2-NP可增强IFN-γ抑制人乳腺癌和纤维肉瘤细胞增殖的能力[1]。

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2-(1,8-萘啶-2-基)苯酚名称

[ CAS 号 ]:
65182-56-1

[ 中文名 ]:
3-氨基-2-氯-6-三氟甲基吡啶

[ 英文名 ]:
3-amino-2-chloro-6-(trifluoromethyl)pyridine

[中文别名 ]:

2-(1,8-萘啶-2-基)苯酚

[英文别名 ]:

2-<o-Hydroxy-phenyl>-1,8-naphthyridin

2-(1,8-萘啶-2-基)苯酚生物活性

[ 描述 ]:

2-NP是STAT1转录的选择性增强子。2-NP可增强IFN-γ抑制人乳腺癌和纤维肉瘤细胞增殖的能力[1]。

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> STAT

研究领域 >> 癌症

信号通路 >> JAK/STAT信号通路 >> STAT

[参考文献]

[1]. Lynch RA, et, al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67(3):1254-61.

2-(1,8-萘啶-2-基)苯酚物理化学性质

[ 熔点 ]:
92-94ºC

[ 分子式 ]:
C₁₄H₁₀N₂O

[ 分子量 ]:
222.24200

[ 精确质量 ]:
222.07900

[ PSA ]:
46.01000

[ LogP ]:
3.00240

[ 外观性状 ]:
orange

[ 储存条件 ]:
room temp

[ 水溶解性 ]:
DMSO: ≥10mg/mL

2-(1,8-萘啶-2-基)苯酚MSDS

详细MSDS(安全技术说明书)

2-(1,8-萘啶-2-基)苯酚安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn,T

[ 风险声明 (欧洲) ]:
22-41-36-25

[ 安全声明 (欧洲) ]:
26-39-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

2-(1,8-萘啶-2-基)苯酚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(1,8-萘啶-2-基)苯酚文献

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This work reports the development of highly fluorescent materials for the selective and efficient detection of picric acid explosive in the nanomolar range by fluorescence quenching phenomenon. Poly(v...

B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.

J. Immunol. 194(7) , 3065-78, (2015)

Class switch DNA recombination (CSR) is central to the maturation of the Ab response because it diversifies Ab effector functions. Like somatic hypermutation, CSR requires activation-induced cytidine ...

Design of a surface-immobilized 4-nitrophenol molecularly imprinted polymer via pre-grafting amino functional materials on magnetic nanoparticles.

J. Chromatogr. A. 1364 , 12-9, (2014)

In order to resolve the low adsorption capacity of the surface molecularly imprinting methods, an approach was developed for the preparation of magnetic imprinted polymers by pre-grafting the amino fu...

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