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Altholactone

Altholactone用途

Goniothalenol 是一种从 Goniothalamus griffithii 中分离得到的苯乙烯内酯。Goniothalenol 对 A2780、HCT-8、KB 和 MCF-7 细胞系具有细胞毒活性。

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Altholactone名称

[ CAS 号 ]:
65408-91-5

[ 英文名 ]:
Altholactone

[英文别名 ]:

2-phenyl-3-hydroxy-6,7-dihydro-furano-pyrone
goniothalenol

Altholactone生物活性

[ 描述 ]:

Goniothalenol 是一种从 Goniothalamus griffithii 中分离得到的苯乙烯内酯。Goniothalenol 对 A2780、HCT-8、KB 和 MCF-7 细胞系具有细胞毒活性。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Zhang, Y. J., et al. Styryllactones from the Rhizomes ofGoniothalamus griffithii. Journal of Asian Natural Products Research, 1(3), 189–197.

Altholactone物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
490.4±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₃H₁₂O₄

[ 分子量 ]:
232.23

[ 闪点 ]:
196.1±22.2 °C

[ 精确质量 ]:
232.073563

[ PSA ]:
55.76000

[ LogP ]:
1.00

[ 外观性状 ]:
油状物体

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
?20°C

Altholactone安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
25

[ 安全声明 (欧洲) ]:
45

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

Altholactone文献

Stereoselective total synthesis of bioactive styryllactones (+)-goniofufurone, (+)7-epi-goniofufurone, (+)-goniopypyrone, (+)-goniotriol, (+)-altholactone, and (-)-etharvensin.

J. Org. Chem. 73(1) , 2-11, (2008)

Stereoselective total synthesis of biologically active styryllactones 7-epi-goniofufurone, goniofufurone, goniopypyrone, goniotriol, altholactone, and etharvensin was achieved in high overall yields f...

The cytotoxicity of naturally occurring styryl lactones.

Phytomedicine 13(3) , 181-6, (2006)

We extracted and isolated three natural styryl lactones from Goniothalamus griffithii Hook f. Thoms and investigated their cytotoxicity on a panel of three hepatocyte cell lines, HepG2, drug resistant...

Asymmetric synthesis of (+)-altholactone: a styryllactone isolated from various Goniothalamus species.

Chemistry 14(9) , 2842-9, (2008)

The asymmetric total synthesis of (+)-altholactone (1), a member of the styryllactone family of natural products displaying cytotoxic and antitumor activities, is described. Key steps include a RAMP-h...

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