二苯乙醇酸-3-奎宁环酯

二苯乙醇酸-3-奎宁环酯名称

[ CAS 号 ]:
6581-06-2

[ 中文名 ]:
二苯乙醇酸-3-奎宁环酯

[ 英文名 ]:
3-Quinuclidinyl benzilate

[中文别名 ]:

3-二苯羟乙酸奎宁脂

[英文别名 ]:

ea2277
Ro 2-330
ro2-3308
CS 4030
3-Benziloyloxyquinuclidine
3-Chinuclidylbenzilate
(+/-)-3-quinuclidinyl benzilate
quinuclidinyl benzilate

二苯乙醇酸-3-奎宁环酯物理化学性质

[ 密度 ]:
1.25g/cm3

[ 沸点 ]:
439ºC at 760 mmHg

[ 熔点 ]:
164ºC

[ 分子式 ]:
C₂₁H₂₃NO₃

[ 分子量 ]:
337.41200

[ 闪点 ]:
219.3ºC

[ 精确质量 ]:
337.16800

[ PSA ]:
49.77000

[ LogP ]:
2.49780

[ 外观性状 ]:
powder | white

[ 折射率 ]:
1.637

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

[ 水溶解性 ]:
chloroform: but decomposes within 24 hrssoluble

二苯乙醇酸-3-奎宁环酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD4638000

CHEMICAL NAME :: Benzilic acid, 3-quinuclidinyl ester

CAS REGISTRY NUMBER :: 6581-06-2

LAST UPDATED :: 199604

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C21-H23-N-O3

MOLECULAR WEIGHT :: 337.45

WISWESSER LINE NOTATION :: T66 A B CNTJ AOVXQR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4500 ng/kg

TOXIC EFFECTS :: Cardiac - change in rate

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4800 ng/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic Behavioral - hallucinations, distorted perceptions Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human

DOSE/DURATION :: 5 ug/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - ataxia Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 103 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TEST SYSTEM :: Rodent - hamster

DOSE/DURATION :: 40 mg/kg/6H (Intermittent)

REFERENCE :: ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague 1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 17,253,1975

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二苯乙醇酸-3-奎宁环酯安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 2811 6.1 / PGII

[ WGK德国 ]:
3

[ RTECS号 ]:
DD4638000

[ 海关编码 ]:
2933391000

二苯乙醇酸-3-奎宁环酯合成路线

详细合成路线

二苯乙醇酸-3-奎宁环酯海关

[ 海关编码 ]: 2933391000

[ 中文概述 ]:
2933391000 二苯乙醇酸-3-奎宁环酯〔即BZ〕。监管条件:23(两用物项和技术进口许可证,两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ 监管条件 ]: 2.两用物项和技术进口许可证 3.两用物项和技术出口许可证

[ Summary ]:
2933391000 quinuclidin-3-yl 2-hydroxy-2,2-diphenylacetate。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

二苯乙醇酸-3-奎宁环酯文献

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J. Pharmacol. Sci. 112(4) , 444-51, (2010)

Muscarinic acetylcholine receptors (mAChRs) of rat cerebral cortex were evaluated using a tissue segment radioligand binding assay. [(3)H]-Quinuclidinyl benzilate (QNB, a hydrophobic ligand) specifica...

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