左旋肉碱盐酸盐

左旋肉碱盐酸盐用途

L-Carnitine hydrochloride 是一种高度极性的小两性离子,是线粒体β-氧化途径的重要共因子。L-Carnitine hydrochloride 的作用是将长链脂肪酰基辅酶 A 转运到线粒体中,通过 β-氧化降解。L-Carnitine hydrochloride 是一种抗氧化剂。L-Carnitine hydrochloride 可以改善许多先天性代谢错误的代谢失衡。

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左旋肉碱盐酸盐名称

[ CAS 号 ]:
6645-46-1

[ 中文名 ]:
左旋肉碱盐酸盐

[ 英文名 ]:
L-Carnitine hydrochloride

[中文别名 ]:

[英文别名 ]:

(−)-β-Hydroxy-γ-(trimethylammonio)butyrate
Vitamin BT Hydrochloride
Carnitine chloride
L-CARNITINE HYDROCHLORIDE
MFCD00066100
L(-)-Carnitine hydrochloride
LEVOCARNITINE HYDROCHLORIDE
QV1YQ1K1&1&1 &&Anhydro HCl
DL-Carnitine Hydrochloride
EINECS 229-663-6

左旋肉碱盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体内研究]

左旋肉碱盐酸盐((R)-肉碱盐酸盐)(125250 mg/kg；i.p.)在慢性小鼠哮喘模型中具有更显著的支气管扩张作用,并减少尿LTE4排泄[4]。动物模型：8-10周龄,体重28-30g BALB/c小鼠[4]剂量：125250 mg/kg给药：i.p.结果：250 mg/kg时SaO2显著升高,尿芳基4排泄减少。

[参考文献]

[1]. Agarwal A, et al. Role of L-carnitine in female infertility. eprod Biol Endocrinol. 2018 Jan 26;16(1):5.

[2]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675.

[3]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675.

[4]. Uzuner N, et al. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301.

左旋肉碱盐酸盐物理化学性质

[ 熔点 ]:
142 °C

[ 分子式 ]:
C₇H₁₆ClNO₃

[ 分子量 ]:
197.660

[ 精确质量 ]:
197.081863

[ PSA ]:
60.36000

[ 外观性状 ]:
白色至略米色结晶粉末

[ 储存条件 ]:
库房低温通风干燥

[ 水溶解性 ]:
soluble

左旋肉碱盐酸盐MSDS

详细MSDS(安全技术说明书)

左旋肉碱盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP2979100

CHEMICAL NAME :: Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, chloride, (-)-

CAS REGISTRY NUMBER :: 6645-46-1

LAST UPDATED :: 199703

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C7-H15-N-O3.Cl

MOLECULAR WEIGHT :: 196.68

WISWESSER LINE NOTATION :: QV1YQ1K1&1&1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6890 mg/kg

TOXIC EFFECTS :: Vascular - other changes Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,191,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1920 mg/kg

TOXIC EFFECTS :: Vascular - other changes Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,191,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure) Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,191,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1440 mg/kg

TOXIC EFFECTS :: Vascular - other changes Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,191,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1690 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4320 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2272 mg/kg

TOXIC EFFECTS :: Vascular - other changes Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,238,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5400 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 728 gm/kg/52W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,221,1988 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 33 gm/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - behavioral

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,465,1988

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左旋肉碱盐酸盐安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
BP2979100

[ 海关编码 ]:
2923900090

左旋肉碱盐酸盐上下游产品

左旋肉碱盐酸盐上游产品

左旋肉碱盐酸盐下游产品

左旋肉碱盐酸盐海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

左旋肉碱盐酸盐文献

Amelioration of palmitate-induced metabolic dysfunction in L6 muscle cells expressing low levels of receptor-interacting protein 140.

Can. J. Physiol. Pharmacol. 93 , 913-22, (2015)

We have shown that reduced expression of receptor-interacting protein 140 (RIP140) alters the regulation of fatty-acid (FA) oxidation in muscle. To determine whether a high level of FA availability al...

To Break or to Brake Neuronal Network Accelerated by Ammonium Ions?

PLoS ONE 10 , e0134145, (2015)

The aim of present study was to investigate the effects of ammonium ions on in vitro neuronal network activity and to search alternative methods of acute ammonia neurotoxicity prevention.Rat hippocamp...

Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.

J. Biol. Chem. 285 , 27449-27456, (2010)

Pathological forms of left ventricular hypertrophy (LVH) often progress to heart failure. Specific transcription factors have been identified that activate the gene program to induce pathological form...

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