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2-氮己环酮

2-氮己环酮用途

2-Piperidone 是一种内源性代谢产物。

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2-氮己环酮名称

[ CAS 号 ]:
675-20-7

[ 中文名 ]:
2-氮己环酮

[ 英文名 ]:
2-Piperidone

[中文别名 ]:

[英文别名 ]:

2-Piperidone
5-pentanelactam
i-valerolactam
Valerolactam
EINECS 211-622-9
δ-valerolactam
2-oxo-piperidine
Piperidin-2-on
piperidone
a-Piperidone

2-氮己环酮生物活性

[ 描述 ]:

2-Piperidone 是一种内源性代谢产物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

2-氮己环酮物理化学性质

[ 密度 ]:
1.073

[ 沸点 ]:
256-262 ºC

[ 熔点 ]:
38-40 °C(lit.)

[ 分子式 ]:
C₅H₉NO

[ 分子量 ]:
99.131

[ 闪点 ]:
147 ºC

[ 精确质量 ]:
99.068413

[ PSA ]:
29.10000

[ LogP ]:
-0.45

[ 外观性状 ]:
白色至淡黄色低熔点结晶块

[ 蒸汽压 ]:
0.1±0.9 mmHg at 25°C

[ 折射率 ]:
1.539

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
291 g/L (25 ºC)

2-氮己环酮MSDS

2-氮己环酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TO0110000

CHEMICAL NAME :: 2-Piperidone

CAS REGISTRY NUMBER :: 675-20-7

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C5-H9-N-O

MOLECULAR WEIGHT :: 99.15

WISWESSER LINE NOTATION :: T6NVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571235

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 60,1058,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 93,143,1953

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Cardiac - other changes

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 50,199,1903

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2-氮己环酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37

[ 安全声明 (欧洲) ]:
S22-S24/25-S37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TO0110000

[ 海关编码 ]:
29337900

2-氮己环酮合成路线

2-氮己环酮上下游产品

2-氮己环酮上游产品

2-氮己环酮下游产品

2-氮己环酮海关

[ 海关编码 ]: 2933790090

[ 中文概述 ]:
2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:9.0% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

2-氮己环酮文献

The chemistry of escapin: identification and quantification of the components in the complex mixture generated by an L-amino acid oxidase in the defensive secretion of the sea snail Aplysia californica.

Chemistry 15(7) , 1597-603, (2009)

Escapin is an L-amino acid oxidase in the ink of a marine snail, the sea hare Aplysia californica, which oxidizes L-lysine (1) to produce a mixture of chemicals which is antipredatory and antimicrobia...

Biosynthesis of 5-aminopentanoic acid and 2-piperidone from cadaverine and 1-piperideine in mouse.

J. Neurochem. 43(6) , 1631-4, (1984)

1-Piperideine, 5-aminopentanoic acid, and its lactam, 2-piperidone, were identified as metabolites of cadaverine in 10,000 g mouse liver supernatants to which diamine oxidase had been added. Both meta...

Rhodium-catalyzed asymmetric 1,4-addition of organoboron reagents to 5,6-dihydro-2(1H)-pyridinones. Asymmetric synthesis of 4-aryl-2-piperidinones.

J. Org. Chem. 66(21) , 6852-6, (2001)

Catalytic asymmetric synthesis of 4-aryl-2-piperidinones was realized for the first time by asymmetric 1,4-addition of arylboron reagents to 5,6-dihydro-2(1H)-pyridinones in the presence of a chiral b...

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