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(D-PYR1,D-PHE2,D-TRP3·6)-LHRH

(D-PYR1,D-PHE2,D-TRP3·6)-LHRH用途

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH是一种黄体生成素释放激素(LHRH)类似物。[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH作为GnRH受体拮抗剂[1]。

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(D-PYR1,D-PHE2,D-TRP3·6)-LHRH名称

[ CAS 号 ]:
68059-94-9

[ 中文名 ]:
(D-PYR1,D-PHE2,D-TRP3·6)-LHRH

[ 英文名 ]:
[DGlp1,DPhe2,DTrp3,6]-LH-RH

[英文别名 ]:

D-pglu1,D-phe2,D-trp3,6-luteinizing*hormone relea
pglu(1)-phe(2)-trp(3,6)-lhr
LHRH,pGlu(1)-Phe(2)-Trp(3,6)
[D-PGLU1,D-PHE2,D-TRP3,6]-LH-RH
[D-PYR1,D-PHE2,D-TRP3,6]-LH-RH (HUMAN)
(D-PYR1,D-PHE2,D-TRP3,6)-LHRH
DGLP-DPHE-DTRP-SER-TYR-DTRP-LEU-ARG-PRO-GLY-NH2
[D-PYROGLU1,D-PHE2,D-TRP3,6]-LH-RH
(D-Pyr1,D-Phe2,D-Trp3

(D-PYR1,D-PHE2,D-TRP3·6)-LHRH生物活性

[ 描述 ]:

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH是一种黄体生成素释放激素(LHRH)类似物。[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH作为GnRH受体拮抗剂[1]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> GNRH受体

研究领域 >> 内分泌

[ 靶点 ]

GnRH receptor[1]

[体外研究]

[D-Glp1、D-Phe2、D-Trp3,6]-LH-RH(1μM)与LH-RH和FSH一起阻断了对FSH诱导的大鼠卵巢颗粒细胞类固醇生成的抑制[3]。

[体内研究]

[D-Glp1、D-Phe2、D-Trp3,6]-LH-RH(1.25和2.5 mg,皮下注射,每天两次,持续7天)延长大鼠妊娠[1]。[D-Glp1、D-Phe2、D-Trp3,6]-LH-RH(250μg)可100%抑制大鼠排卵[2]。

(D-PYR1,D-PHE2,D-TRP3·6)-LHRH物理化学性质

[ 分子式 ]:
C₆₇H₈₄N₁₆O₁₃

[ 分子量 ]:
1321.48000

[ 精确质量 ]:
1320.64000

[ PSA ]:
459.24000

[ LogP ]:
4.47690

(D-PYR1,D-PHE2,D-TRP3·6)-LHRHMSDS

详细MSDS(安全技术说明书)

(D-PYR1,D-PHE2,D-TRP3·6)-LHRH安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R60

[ 安全声明 (欧洲) ]:
53-22-36/37/39-45

[ 危险品运输编码 ]:
NONH for all modes of transport

(D-PYR1,D-PHE2,D-TRP3·6)-LHRH文献

Characterization of Leydig cell gonadotropin-releasing hormone binding sites utilizing radiolabeled agonist and antagonist.

Peptides 3(5) , 789-92, (1982)

Gonadotropin-releasing hormone (GnRH) binding sites in intact Leydig cells and in membrane preparations were investigated using 125I-labeled GnRH agonist and antagonist. Binding was saturable and invo...

Role of lipids in gonadotropin releasing hormone agonists and antagonist binding to rat pituitary.

Biochem. Biophys. Res. Commun. 105(1) , 8-13, (1982)

Digestion of pituitary membranes with phospholipase A 2 and phospholipase C abolished, in a dose responsive manner, the specific binding of gonadotropin releasing hormone agonist and antagonist. These...

LH-RH analogue acts as substance P antagonist by inhibiting spinal cord vasomotor responses.

Brain Res. 337(2) , 357-61, (1985)

Intrathecal injections of the luteinizing hormone-releasing hormone (LH-RH) analogue, [D-pGlu1-D-Phe2-D-Trp3,6]-LH-RH caused dose-dependent decreases in mean arterial blood pressure in anesthetized ra...

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