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ddGTP

ddGTP用途

ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) 是一类双脱氧核糖核苷酸 (ddNTPs),可作为 DNA 聚合酶链延长抑制剂用于 DNA 测序。

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ddGTP名称

[ CAS 号 ]:
68726-28-3

[ 中文名 ]:
2',3'-脱氧鸟苷5'-三磷酸钠盐

[ 英文名 ]:
ddGTP

[英文别名 ]:

2',3'-dideoxyguanosine 5'-triphosphate sodium salt

ddGTP生物活性

[ 描述 ]:

ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) 是一类双脱氧核糖核苷酸 (ddNTPs),可作为 DNA 聚合酶链延长抑制剂用于 DNA 测序。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

研究领域 >> 其他

[参考文献]

[1]. Z G Chidgeavadze, et al. 3'-Fluoro-2',3'-dideoxyribonucleoside 5'-triphosphates: terminators of DNA synthesis. FEBS Lett. 1985 Apr 22;183(2):275-8.

ddGTP物理化学性质

[ 分子式 ]:
C₁₀H₁₆N₅O₁₂P₃

[ 分子量 ]:
491.18200

[ 精确质量 ]:
491.00100

[ PSA ]:
288.07000

[ LogP ]:
0.30390

[ 储存条件 ]:
2-8°C，密封，干燥

ddGTP安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

ddGTP文献

Selective enzymatic cleavage and labeling for sensitive capillary electrophoresis laser-induced fluorescence analysis of oxidized DNA bases.

J. Chromatogr. A. 1406 , 324-30, (2015)

Oxidatively generated DNA damage is considered to be a significant contributing factor to cancer, aging, and age-related human diseases. It is important to detect oxidatively generated DNA damage to u...

Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly.

Proc. Natl. Acad. Sci. U. S. A. 112 , E4707-16, (2015)

Ribosome biogenesis requires multiple assembly factors. In Escherichia coli, deletion of RlmE, the methyltransferase responsible for the 2'-O-methyluridine modification at position 2552 (Um2552) in he...

DNA sequencing with chain-terminating inhibitors.

Proc. Natl. Acad. Sci. U. S. A. 74 , 5463, (1977)

A new method for determining nucleotide sequences in DNA is described. It is similar to the "plus and minus" method [Sanger, F. & Coulson, A. R. (1975) J. Mol. Biol. 94, 441-448] but makes use of the ...

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