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氢溴酸加兰他敏

氢溴酸加兰他敏名称

[ CAS 号 ]:
69353-21-5

[ 中文名 ]:
氢溴酸加兰他敏

[ 英文名 ]:
5-METHOXY-9-METHYL-2,3,3A,3A1,8,9,10,11-OCTAHYDRO-4-OXA-9-AZACYCLOOCTA[DEF]FLUOREN-2-OL HYDROBROMIDE

[中文别名 ]:

Galant胺氢溴酸

[英文别名 ]:

2-benzylhexahydro-1H-isoindol-4(2H)-one
(3ARS,7ASR)-2-benzyl-4-perhydroisoindolone
11-Hydroxycephalotaxin
11-hydroxycephalotaxine

氢溴酸加兰他敏物理化学性质

[ 密度 ]:
1.593 g/cm3

[ 沸点 ]:
630.4ºC at 760 mmHg

[ 熔点 ]:
287ºC decomposes

[ 分子式 ]:
C₁₂H₈O₂

[ 分子量 ]:
184.19100

[ 闪点 ]:
335ºC

[ 精确质量 ]:
184.05200

[ PSA ]:
18.46000

[ LogP ]:
3.58460

[ 储存条件 ]:
−20°C

氢溴酸加兰他敏毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF8075000

CHEMICAL NAME :: Benzofuro(4,3,2-efg)(2)benzazocin-6-ol, 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, hydrobromide

CAS REGISTRY NUMBER :: 69353-21-5

LAST UPDATED :: 199212

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C17-H21-N-O3.Br-H

MOLECULAR WEIGHT :: 368.31

WISWESSER LINE NOTATION :: T766 C6/CM B 2AC Q CX EN LO PUT&TTJ E1 JO1 OQ &EH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 32,301,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 32,301,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHABA8 Chemical Abstracts. (Chemical Abstracts Service, Box 3012, Columbus, OH 43210) V.1- 1907- Volume(issue)/page/year: 66,53993v,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 7,402,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15400 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,168,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5200 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,347,1961 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993

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氢溴酸加兰他敏安全信息

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DF8075000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2942000000

氢溴酸加兰他敏海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%