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氢溴酸加兰他敏

氢溴酸加兰他敏用途

Galanthamine氢溴酸盐是长效的中心活性的乙酰胆碱酯酶(AChE)抑制剂,IC50为410 nM,同时是神经元烟碱乙酰胆碱受体的变构增强剂。

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氢溴酸加兰他敏名称

[ CAS 号 ]:
1953-04-4

[ 中文名 ]:
氢溴酸加兰他敏

[ 英文名 ]:
Galantamine hydrobromide

[中文别名 ]:

[英文别名 ]:

NIVALIN,HBR
MFCD00067672
Galanthamine hydrobromide (1:1)
GALANTHAMIDE HYDROBROMIDE
[3H]-Galantamine hydrobromide
UNII:5N4SA4KQX9
galanthamine bromhydrate (1:1)
Galantamine hydrobromide (JAN/USAN)
Galanthamine HBr
Galanthamine (hydrobromide)

氢溴酸加兰他敏生物活性

[ 描述 ]:

Galanthamine氢溴酸盐是长效的中心活性的乙酰胆碱酯酶(AChE)抑制剂,IC50为410 nM,同时是神经元烟碱乙酰胆碱受体的变构增强剂。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 疼痛

研究领域 >> 神经疾病

[参考文献]

[1]. Kita Y, Ago Y, Takano E, Fukada A, Takuma K, Matsuda T.Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice.Psychopharmacology (Berl). 2012 Aug 30.

[2]. Berkov S, Viladomat F, Codina C, Suárez S, Ravelo A, Bastida J.GC-MS of amaryllidaceous galanthamine-type alkaloids.J Mass Spectrom. 2012 Aug;47(8):1065-73.

[3]. Park CW, Son DD, Kim JY, Oh TO, Ha JM, Rhee YS, Park ES.Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.Int J Pharm. 2012 Oct 15;436(1-2):32-40. Epub 2012 Jul 5.

[4]. Park YS, Kim SH, Kim SY, Kim YH, Lee MH, Yang SC, Shaw LM, Kang JS.Quantification of Galantamine in Human Plasma by Validated Liquid Chromatography-Tandem Mass Spectrometry using Glimepride as an Internal Standard: Application to Bioavailability Studies in 32 Healthy Korean Subjects.J Chromatogr Sci. 2012 Jun 28.

[5]. Arias et al Galantamine prevents apoptosis induced by b-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology (2004) 46 103.

[相关活性小分子]

氢溴酸加兰他敏物理化学性质

[ 熔点 ]:
256 °C

[ 分子式 ]:
C₁₇H₂₂BrNO₃

[ 分子量 ]:
368.266

[ 精确质量 ]:
367.078308

[ PSA ]:
41.93000

[ LogP ]:
2.74630

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
-95 ° (C=1.4, H2O)

[ 储存条件 ]:
−20°C

氢溴酸加兰他敏MSDS

氢溴酸加兰他敏安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R25:Toxic if swallowed.

[ 安全声明 (欧洲) ]:
45-36/37/39-22

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DF8075000

氢溴酸加兰他敏合成路线

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氢溴酸加兰他敏文献

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

J. Chromatogr. A. 1374 , 122-33, (2014)

The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...

Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases.

Nanoscale 7 , 12076-84, (2015)

Polymeric nanoparticles could be promising drug delivery systems to treat neurodegenerative diseases. Among the various methods of nanoparticle preparation, nano-emulsion templating was used in the pr...

Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.

J. Neurophysiol. 113 , 2195-209, (2015)

The neuromodulator acetylcholine (ACh) shapes neocortical function during sensory perception, motor control, arousal, attention, learning, and memory. Here we investigate the mechanisms by which ACh a...

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氢溴酸加兰他敏

氢溴酸加兰他敏用途

氢溴酸加兰他敏名称

氢溴酸加兰他敏生物活性

氢溴酸加兰他敏物理化学性质

氢溴酸加兰他敏MSDS

详细MSDS(安全技术说明书)

氢溴酸加兰他敏安全信息

氢溴酸加兰他敏合成路线

详细合成路线

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