氧化抗震颤素
氧化抗震颤素名称
[ CAS 号 ]:
70-22-4
[ 中文名 ]:
氧化抗震颤素
[ 英文名 ]:
OXOTREMORINE
[中文别名 ]:
[英文别名 ]:
- oxotremorine M
- Tremorine,oxo
- Oxotremorin
- 2'-Oxopyrrolidino-1-pyrrolidino-4-butyne
- Oxotremorine
- EINECS 200-728-0
- oxotremorin-M
- Oxytremorine
氧化抗震颤素物理化学性质
[ 密度 ]:
1.109g/cm3
[ 沸点 ]:
373.9ºC at 760 mmHg
[ 分子式 ]:
C12H18N2O
[ 分子量 ]:
206.28400
[ 闪点 ]:
169.1ºC
[ 精确质量 ]:
206.14200
[ PSA ]:
23.55000
[ LogP ]:
0.58380
[ 折射率 ]:
1.544
氧化抗震颤素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY5950100
- CHEMICAL NAME :
- 2-Pyrrolidinone, 1-(4-(1-pyrrolidinyl)-2-butynyl)-
- CAS REGISTRY NUMBER :
- 70-22-4
- BEILSTEIN REFERENCE NO. :
- 1530948
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C12-H18-N2-O
- MOLECULAR WEIGHT :
- 206.32
- WISWESSER LINE NOTATION :
- T5NVTJ A2UU2- AT5NTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 7 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 144,468,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 10 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 144,468,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,67,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1220 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,560,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HPFSDS HHS Publication (FDA. United States). (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) 1980- Volume(issue)/page/year: FDA-80-1076,212,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic
- REFERENCE :
- ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 29,39,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1382 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 28,1760,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 162 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - bronchiolar constriction
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 57,1543,1968
点击显示
氧化抗震颤素安全信息
[ 危害码 (欧洲) ]:
T+,C
[ 风险声明 (欧洲) ]:
28-34
[ 危险品运输编码 ]:
UN 2810 6.1/PG 1
[ 危险类别 ]:
6.1(a)
氧化抗震颤素合成路线
氧化抗震颤素上下游产品
氧化抗震颤素上游产品
氧化抗震颤素下游产品
推荐生产厂家/供应商：
暂无推荐供应商。请联系客服获知如何成为推荐供应商。
相关化合物
【氧化抗震颤素】化源网提供氧化抗震颤素CAS号70-22-4，氧化抗震颤素MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询氧化抗震颤素上化源网，专业又轻松。>>电脑版：氧化抗震颤素
标题：氧化抗震颤素_密度_沸点_分子量_氧化抗震颤素CAS号【70-22-4】_化源网 地址：https://m.chemsrc.com/mip/cas/70-22-4_671766.html