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Pimonidazole hydrochloride

Pimonidazole hydrochloride用途

Pimonidazole 是一种缺氧标记物,用于瘤内缺氧和细胞增殖的补充性研究。Pimonidazole 通过与大分子的共价结合或通过被还原形成还原性代谢物后在缺氧细胞中积累,可用于定性和定量评估肿瘤缺氧。

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Pimonidazole hydrochloride名称

[ CAS 号 ]:
70132-51-3

[ 英文名 ]:
Pimonidazole hydrochloride

[英文别名 ]:

Ro 03-8799
Pimonidazole hydrochloride
Pimonidazole HCl

Pimonidazole hydrochloride生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7.

[2]. Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639.

Pimonidazole hydrochloride物理化学性质

[ 沸点 ]:
490.5ºC at 760 mmHg

[ 分子式 ]:
C₁₁H₁₉ClN₄O₃

[ 分子量 ]:
290.74700

[ 闪点 ]:
250.5ºC

[ 精确质量 ]:
290.11500

[ PSA ]:
87.11000

[ LogP ]:
1.90120

[ 储存条件 ]:
-20°C，密闭，干燥

Pimonidazole hydrochloride毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM9465000

CHEMICAL NAME :: 1-Piperidineethanol, alpha-((2-nitro-1H-imidazol-1-yl)methyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 70132-51-3

LAST UPDATED :: 198709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H18-N4-O3.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IOBPD3 International Journal of Radiation Oncology, Biology, Physics. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1975- Volume(issue)/page/year: 12,1097,1986