2,3-萘基二缩醛

2,3-萘基二缩醛用途

Naphthalene-2,3-Dicarboxaldehyde (2,3-Naphthalenedicarboxaldehyde), a phthaldehyde derivative, is a fungal ASADH inhibitor (Ki: 45 渭M). Naphthalene-2,3-Dicarboxaldehyde inhibits the growth of C. albicans CAF2-1 with IC50 of 58.2 渭M and MIC of 12 渭g/mL[1].

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2,3-萘基二缩醛名称

[ CAS 号 ]:
7149-49-7

[ 中文名 ]:
2,3-萘二甲醛

[ 英文名 ]:
2,3-Naphthalenedicarbaldehyde

[中文别名 ]:

[英文别名 ]:

2,3-Naphthalenedicarbaldehyde
Naphthalene-2,3-dicarbaldehyde
MFCD00016618
2,3-Naphthalenedicarboxaldehyde
NAPHTHALENE-2,3-DICARBOXALDEHYDE

2,3-萘基二缩醛生物活性

[ 描述 ]:

萘-2,3-二甲醛(2,3-萘二甲醛)是一种邻苯二甲醛衍生物,是一种真菌ASADH抑制剂(Ki:45渭M) 。萘-2,3-二甲醛抑制白色念珠菌CAF2-1生长的IC50为58.2渭M和MIC为12渭g/mL[1]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Dahal GP, et al. Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans. Drug Dev Res. 2020 Sep;81(6):736-744.

2,3-萘基二缩醛物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
380.0±25.0 °C at 760 mmHg

[ 熔点 ]:
131-133ºC(lit.)

[ 分子式 ]:
C₁₂H₈O₂

[ 分子量 ]:
184.19

[ 闪点 ]:
142.5±20.2 °C

[ 精确质量 ]:
184.052429

[ PSA ]:
34.14000

[ LogP ]:
1.74

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.713

[ 储存条件 ]:
2-8°C

2,3-萘基二缩醛MSDS

详细MSDS(安全技术说明书)

2,3-萘基二缩醛安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2912299000

2,3-萘基二缩醛合成路线

详细合成路线

2,3-萘基二缩醛上下游产品

2,3-萘基二缩醛上游产品

2,3-萘基二缩醛下游产品

2,3-萘基二缩醛海关

[ 海关编码 ]: 2912299000

[ 中文概述 ]:
2912299000. 其他不含其他含氧基的环醛. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 四聚甲醛报明外观

[ Summary ]:
2912299000. other cyclic aldehydes without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

2,3-萘基二缩醛文献

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Eur. J. Pharm. Sci. 57 , 25-33, (2014)

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Toxicol. Appl. Pharmacol. 282(2) , 195-206, (2015)

The key mechanism for acetaminophen hepatotoxicity is cytochrome P450 (CYP)-dependent formation of N-acetyl-p-benzoquinone imine, a potent electrophile that forms protein adducts. Previous studies rev...

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