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1,1-二氯-2,2-双(4-乙笨)-乙烷

1,1-二氯-2,2-双(4-乙笨)-乙烷用途

p,p'-DDD 是 p,p'-DDT 的主要代谢产物。p,p'-DDD 出现在大鼠的粪便和肝脏中,通过胃管给予 p,p'-DDT,但腹腔注射 p,p'-DDT 的大鼠没有。

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1,1-二氯-2,2-双(4-乙笨)-乙烷名称

[ CAS 号 ]:
72-54-8

[ 中文名 ]:
2,2-双(对氯苯基)-1,1-二氯乙烷

[ 英文名 ]:
p,p'-DDD

[中文别名 ]:

[英文别名 ]:

EINECS 200-783-0
4,4'-DDD
P,P'-DDD
DDD
p,p'-Dichlorodiphenyldichloroethane
1,1’-(2,2-dichloroethylidene)bis[4-chlorobenzene]
1,1-Dichloro-2,2-bis(4-chlorophenyl)-ethane
1,1-Bis(4-chlorophenyl)-2,2-dichloroethane
p,p'-(Dichlorodiphenyl)dichloroethane
2,2-Bis(4-chlorophenyl)-1,1-dichloroethane

1,1-二氯-2,2-双(4-乙笨)-乙烷生物活性

[ 描述 ]:

p,p'-DDD 是 p,p'-DDT 的主要代谢产物。p,p'-DDD 出现在大鼠的粪便和肝脏中,通过胃管给予 p,p'-DDT,但腹腔注射 p,p'-DDT 的大鼠没有。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Mendel JL, et al. Conversion of p,p' -DDT to p,p' -DDD by intestinal flora of the rat. Science. 1966;151(3717):1527-1528.

[2]. Gerić M, et al. Cytogenetic status of human lymphocytes after exposure to low concentrations of p,p'-DDT, and its metabolites (p,p'-DDE, and p,p'-DDD) in vitro. Chemosphere. 2012;87(11):1288-1294.

1,1-二氯-2,2-双(4-乙笨)-乙烷物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
405.7±40.0 °C at 760 mmHg

[ 熔点 ]:
94-96 °C

[ 分子式 ]:
C₁₄H₁₀Cl₄

[ 分子量 ]:
320.041

[ 闪点 ]:
199.3±24.7 °C

[ 精确质量 ]:
317.953674

[ LogP ]:
5.39

[ 外观性状 ]:
无色至灰白色晶体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.599

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：不溶

1,1-二氯-2,2-双(4-乙笨)-乙烷MSDS

1,1-二氯-2,2-双(4-乙笨)-乙烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KI0700000

CHEMICAL NAME :: Ethane, 1,1-dichloro-2,2-bis(p-chlorophenyl)-

CAS REGISTRY NUMBER :: 72-54-8

BEILSTEIN REFERENCE NO. :: 1914072

LAST UPDATED :: 199710

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C14-H10-Cl4

MOLECULAR WEIGHT :: 320.04

WISWESSER LINE NOTATION :: GYGYR DG&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - convulsions or effect on seizure threshold Skin and Appendages - primary irritation (after topical exposure)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 504 mg/kg/6W-C

TOXIC EFFECTS :: Endocrine - changes in spleen weight Immunological Including Allergic - decrease in cellular immune response Immunological Including Allergic - decrease in humoral immune response

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 54 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :: Host-mediated assay

TEST SYSTEM :: Rodent - mouse Bacteria - Serratia marcescens

DOSE/DURATION :: 1500 mg/kg

REFERENCE :: BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881- Volume(issue)/page/year: 91,311,1972 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 5,83,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5013 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated)

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1,1-二氯-2,2-双(4-乙笨)-乙烷安全信息

[ 符号 ]:

GHS02, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370-H410

[ 警示性声明 ]:
P210-P260-P273-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
T,N,F

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S36/37-S45-S60-S61-S16-S7

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
KI0700000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2903999090

1,1-二氯-2,2-双(4-乙笨)-乙烷合成路线

1,1-二氯-2,2-双(4-乙笨)-乙烷制备

由邻溴氯苯制得。

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1,1-二氯-2,2-双(4-乙笨)-乙烷海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

1,1-二氯-2,2-双(4-乙笨)-乙烷文献

Risk assessment for children exposed to DDT residues in various milk types from the Greek market.

Food Chem. Toxicol. 75 , 156-65, (2015)

The occurrence of residues of DDT and its metabolites was monitored in 196 cow milk samples of various pasteurized commercial types collected from the Greek market. Residue levels were determined by G...

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...

Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth.

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 368(1612) , 20120429, (2013)

The fight against diseases spread by mosquitoes and other insects has enormous environmental, economic and social consequences. Chemical insecticides remain the first line of defence but the control o...

更多文献

1,1-二氯-2,2-双(4-乙笨)-乙烷

1,1-二氯-2,2-双(4-乙笨)-乙烷用途

1,1-二氯-2,2-双(4-乙笨)-乙烷名称

1,1-二氯-2,2-双(4-乙笨)-乙烷生物活性

1,1-二氯-2,2-双(4-乙笨)-乙烷物理化学性质

1,1-二氯-2,2-双(4-乙笨)-乙烷MSDS

详细MSDS(安全技术说明书)

1,1-二氯-2,2-双(4-乙笨)-乙烷毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,1-二氯-2,2-双(4-乙笨)-乙烷安全信息

1,1-二氯-2,2-双(4-乙笨)-乙烷合成路线

详细合成路线

1,1-二氯-2,2-双(4-乙笨)-乙烷制备

1,1-二氯-2,2-双(4-乙笨)-乙烷海关

1,1-二氯-2,2-双(4-乙笨)-乙烷文献

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