美雄酮
美雄酮用途
用途二：用于慢性消耗性疾病、小儿发育不良、骨质疏松、高血脂症等。
美雄酮名称
[ CAS 号 ]:
72-63-9
[ 中文名 ]:
美雄酮
[ 英文名 ]:
Metandienone
[中文别名 ]:
[英文别名 ]:
- 1-Dehydro-17a-methyltestosterone
- Androsta-1,4-dien-3-one, 17β-hydroxy-17α-methyl-
- Androsta-1,4-dien-3-one, 17β-hydroxy-17-methyl-
- 1-Dehydro-17α-methyltestosterone
- EINECS 200-787-2
- (17β)-17-Hydroxy-17-methylandrosta-1,4-dien-3-one
- 17a-Methyl-17b-hydroxyandrosta-1,4-dien-3-one
- Metandienone
- (17b)-17-Hydroxy-17-methylandrosta-1,4-dien-3-one
- Nabolin
美雄酮物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
436.5±45.0 °C at 760 mmHg
[ 熔点 ]:
165-166 °C
[ 分子式 ]:
C20H28O2
[ 分子量 ]:
300.435
[ 闪点 ]:
186.2±21.3 °C
[ 精确质量 ]:
300.208923
[ PSA ]:
37.30000
[ LogP ]:
4.04
[ 外观性状 ]:
白色至灰白色结晶粉末
[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C
[ 折射率 ]:
1.572
[ 储存条件 ]:
2-8°C
美雄酮MSDS
美雄酮毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BV8000000
- CHEMICAL NAME :
- Androsta-1,4-dien-3-one, 17-beta-hydroxy-17-alpha-methyl-
- CAS REGISTRY NUMBER :
- 72-63-9
- LAST UPDATED :
- 199504
- WISWESSER LINE NOTATION :
- L E5 B666 OV AHTTT&J A1 E1 FQ F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 425 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 561 mg/kg/7Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 13 mg/kg
- SEX/DURATION :
- male 60 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- male 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 7 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg/10D (Intermittent)
- REFERENCE :
- VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952- Volume(issue)/page/year: 38(4),63,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5642 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 157 (estimated) No. of Female Employees: 72 (estimated)
美雄酮安全信息
[ 符号 ]:
GHS02, GHS07, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H315-H360FD
[ 补充危害声明 ]:
May form explosive peroxides.
[ 警示性声明 ]:
P201-P210-P280-P308 + P313-P370 + P378-P403 + P235
[ 危害码 (欧洲) ]:
F,T
[ 风险声明 (欧洲) ]:
60-61-11-19-38
[ 安全声明 (欧洲) ]:
53-45
[ 危险品运输编码 ]:
3249
[ WGK德国 ]:
3
[ RTECS号 ]:
BV8000000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2942000000
美雄酮合成路线
美雄酮上下游产品
美雄酮上游产品
美雄酮下游产品
美雄酮制备
以剑麻皂甙元为原料制得
美雄酮海关
[ 海关编码 ]: 2942000000
美雄酮文献
BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...
Screening for anabolic steroids in urine of forensic cases using fully automated solid phase extraction and LC-MS-MS.J. Anal. Toxicol. 38(9) , 637-44, (2014)
A screening method for 18 frequently measured exogenous anabolic steroids and the testosterone/epitestosterone (T/E) ratio in forensic cases has been developed and validated. The method involves a ful...
Mass spectrometric behavior of anabolic androgenic steroids using gas chromatography coupled to atmospheric pressure chemical ionization source. Part I: ionization.J. Mass Spectrom. 49(6) , 509-21, (2014)
The detection of anabolic androgenic steroids (AAS) is one of the most important topics in doping control analysis. Gas chromatography coupled to (tandem) mass spectrometry (GC-MS(/MS)) with electron ...
相关化工产品/化学物质：
相关药品：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：美雄酮
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥568.0/5g
￥198.0/1g
联系人：刘佳
产品详情：甲醇中美雄酮
公司名：江西瑞威尔生物科技有限公司
区域：吉安市峡江县
价格：
￥6500.0/1kg
￥需询单/100mg
￥需询单/10g
￥需询单/100g
联系人：李经理
产品详情：美雄酮
公司名：西安康诺化工有限公司
区域：西安市雁塔区
价格：
￥需询单/1kg
联系人：高经理
产品详情：美雄酮
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相关化合物
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