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八倾吲嗪三醇

八倾吲嗪三醇用途

Swainsonine 是从紫云英属植物中分离得到的生物碱类,为 α-甘露糖苷酶 (α-mannosidase) 抑制剂,具有抗肿瘤活性。

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八倾吲嗪三醇名称

[ CAS 号 ]:
72741-87-8

[ 中文名 ]:
八倾吲嗪三醇

[ 英文名 ]:
swainsonine

[中文别名 ]:

[英文别名 ]:

D-Swainsonine
(1S,2R,8R,8aR)-Octahydroindolizine-1,2,8-triol
(1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
1,2,8-Indolizinetriol, octahydro-, (1S,2R,8R,8aR)-
8A,B-INDOLIZIDINE-1,2A,8B-TRIOL
Tridolgosir
SwainMoia
UNII-RSY4RK37KQ
swainsonine synthetic
Swainsonine

八倾吲嗪三醇生物活性

[ 描述 ]:

Swainsonine 是从紫云英属植物中分离得到的生物碱类,为 α-甘露糖苷酶 (α-mannosidase) 抑制剂,具有抗肿瘤活性。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Silveira CRF, et al. Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population. PLoS One. 2019 Mar 6;14(3):e0213184.

八倾吲嗪三醇物理化学性质

[ 密度 ]:
1.38±0.1 g/cm3

[ 沸点 ]:
353.3±21.0 °C at 760 mmHg

[ 熔点 ]:
144-145 ºC

[ 分子式 ]:
C₈H₁₅NO₃

[ 分子量 ]:
173.210

[ 闪点 ]:
209.7±20.7 °C

[ 精确质量 ]:
173.105194

[ PSA ]:
63.93000

[ LogP ]:
-0.79

[ 外观性状 ]:
冻干的粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.609

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Freely soluble (170 g/L) (25 ºC)

八倾吲嗪三醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NM2408666

[ 海关编码 ]:
29339900

八倾吲嗪三醇合成路线

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八倾吲嗪三醇文献

Production, HPLC analysis, and in situ apoptotic activities of swainsonine toward lepidopteran, Sf-21 cell line.

Biotechnol. Prog. 30(5) , 1196-205, (2014)

Swainsonine, a secondary metabolite from Metarhizium anisopliae has been extensively studied in the complementary areas of therapeutics and toxicology. This work aims to develop a simple UV-HPLC metho...

DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.

Nucleic Acids Res. 39 , D1035-41., (2011)

DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, ...

Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo.

Oncol. Rep. 28(6) , 2091-100, (2012)

Swainsonine, an extract from Astragalus membranaceus, exhibits broad inhibition of growth and pro-apoptotic activity in a number of tumor types. However, the underlying mechanism involved remains uncl...

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