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苄氟噻嗪

苄氟噻嗪用途

苯卓氟甲肼是一种口服利尿剂。苯卓氟甲基噻嗪是一种抗高血压药物。苯卓氟甲基噻嗪在动脉性高血压疾病的研究中具有潜力[1]。

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苄氟噻嗪名称

[ CAS 号 ]:
73-48-3

[ 中文名 ]:
苄氟噻嗪

[ 英文名 ]:
bendroflumethiazide

[中文别名 ]:

[英文别名 ]:

Pluryl
benzoflumethiazide
Bendrofluazide
Naturetin
Benzydroflumethiazide
Centyl
Benzylrodiuran
Berkozide
bendroflumethiazide
bendroflumethazide

苄氟噻嗪生物活性

[ 描述 ]:

苯卓氟甲肼是一种口服利尿剂。苯卓氟甲基噻嗪是一种抗高血压药物。苯卓氟甲基噻嗪在动脉性高血压疾病的研究中具有潜力[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. GRIEBLE HG, et al. Treatment of arterial hypertensive disease with diuretics. I. Effects on blood pressure of bendroflumethiazide, potassium chloride, and spironolactone. Arch Intern Med. 1962;110:26-33.

苄氟噻嗪物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
602.1±65.0 °C at 760 mmHg

[ 熔点 ]:
205-207ºC

[ 分子式 ]:
C₁₅H₁₄F₃N₃O₄S₂

[ 分子量 ]:
421.415

[ 闪点 ]:
318.0±34.3 °C

[ 精确质量 ]:
421.037781

[ PSA ]:
135.12000

[ LogP ]:
2.07

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
通风低温干燥

[ 水溶解性 ]:
Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent).

苄氟噻嗪MSDS

苄氟噻嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK8225000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

CAS REGISTRY NUMBER :: 73-48-3

BEILSTEIN REFERENCE NO. :: 0373316

LAST UPDATED :: 199806

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H14-F3-N3-O4-S2

MOLECULAR WEIGHT :: 421.44

WISWESSER LINE NOTATION :: T66 BSWM EM DHJ D1R& HXFFF ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 300 ug/kg/3D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in sodium

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22750 mg/kg/26W-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - changes in calcium Nutritional and Gross Metabolic - changes in metals, not otherwise specified

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3640 mg/kg/26W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Nutritional and Gross Metabolic - changes in potassium

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 200 mg/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981

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苄氟噻嗪安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DK8225000

苄氟噻嗪合成路线

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苄氟噻嗪文献

Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. I: Investigation of mobile phase and MS conditions.

Anal. Chim. Acta 853 , 637-46, (2014)

The conditions for the analysis of selected doping substances by UHPSFC-MS/MS were optimized to ensure suitable peak shapes and maximized MS responses. A representative mixture of 31 acidic and basic ...

Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. II: Analysis of biological samples.

Anal. Chim. Acta 853 , 647-59, (2014)

The potential and applicability of UHPSFC-MS/MS for anti-doping screening in urine samples were tested for the first time. For this purpose, a group of 110 doping agents with diverse physicochemical p...

Binding of diuretic antihypertensive bendroflumethiazide to human serum albumin studied by ¹⁹F nuclear magnetic resonance method.

Eur. J. Pharm. Sci. 45(1-2) , 195-200, (2012)

Simultaneous specific and nonspecific binding of bendroflumethiazide (BFZ) to human serum albumin (HSA) and concentration profile of BFZ in HSA buffer (pH 7.40) solution were investigated by ¹⁹F nucle...

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