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4-BOC-氨基哌啶

4-BOC-氨基哌啶用途

4-Boc-氨基哌啶是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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4-BOC-氨基哌啶名称

[ CAS 号 ]:
73874-95-0

[ 中文名 ]:
4-Boc-氨基哌啶

[ 英文名 ]:
4-(N-BOC-AMINO)PIPERIDINE

[中文别名 ]:

[英文别名 ]:

MFCD00798171
tert-butyl N-piperidin-4-ylcarbamate
tert-butyl-piperidin-4-ylcarbamat
2-Methyl-2-propanyl 4-piperidinylcarbamate
tert-butyl piperidin-4-ylcarbamate
4-(N-BOC-AMINO)PIPERIDINE
4-(tert-Butoxycarbonyl)-aminopiperidine
4-N-BOC-Aminopiperidine
4-N-(tert-Butoxycarbonyl)aminopiperidine

4-BOC-氨基哌啶生物活性

[ 描述 ]:

4-Boc-氨基哌啶是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

4-(N-Boc-氨基)哌啶是一种有机结构单元。它已被用于合成氨基哌啶抗病毒趋化因子 (CC主题)受体 5(CCR5)拮抗剂和抗菌药物。

[参考文献]

[1]. Burrows, JN, Cumming, JG, Fillery, SM, et al. Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas Bioorg. Med. Chem. Lett.15(1 )25-28(2005)

[2]. Reck, F., Alm, R., Brassil, P., et al.Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: Broad-spectrum antibacterial agents with reduced hERG activityJ. Med . Chem.54(22)7834-7847(2011)

4-BOC-氨基哌啶物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
304.8±31.0 °C at 760 mmHg

[ 熔点 ]:
162-166 °C(lit.)

[ 分子式 ]:
C₁₀H₂₀N₂O₂

[ 分子量 ]:
200.28

[ 闪点 ]:
138.2±24.8 °C

[ 精确质量 ]:
200.152481

[ PSA ]:
50.36000

[ LogP ]:
1.32

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.480

[ 储存条件 ]:
室温，干燥，密封

[ 水溶解性 ]:
可溶于：甲醇

4-BOC-氨基哌啶MSDS

4-BOC-氨基哌啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933399090

4-BOC-氨基哌啶合成路线

4-BOC-氨基哌啶上下游产品

4-BOC-氨基哌啶上游产品

4-BOC-氨基哌啶下游产品

4-BOC-氨基哌啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-BOC-氨基哌啶文献

Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity.

J. Med. Chem. 49 , 2784, (2006)

We incorporated various polar groups into previously described piperidine-4-carboxamide CCR5 antagonists to improve their metabolic stability in human hepatic microsomes. Introducing a carbamoyl group...

Synthesis of potent oxindole CDK2 inhibitors.

Bioorg. Med. Chem. 11 , 1873-1881, (2003)

A series of oxindole CDK2 inhibitors was synthesized. These novel analogues have a saturated monosubstituted cyclic moiety at their C-4 position that mimics the ribofuranoside of ATP. This substitutio...

Poly (2-isopropyl-2-oxazoline)-poly (L-glutamate) block copolymers through ammonium-mediated NCA polymerization. Meyer M and Schlaad H.

Macromolecules 39(11) , 3967-3970, (2006)

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